AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
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OECD SIDS<br />
<strong>AMMONIUM</strong> <strong>SULFATE</strong><br />
5. TOXICITY ID: <strong>7783</strong>-<strong>20</strong>-2<br />
DATE: 18.04.<strong>20</strong>06<br />
measured with a maximum after 16 hours. In comparison, an<br />
equimolar dose of NaCl (25.7 mmol = 1500 mg/kg bw) induced a<br />
248 fold increase in enzyme activity.<br />
The authors concluded that the various tested salts may have<br />
the capability of tumor promotion in the glandular stomach<br />
of rats.<br />
Test condition: Male Fischer 344 rats, 7 to 8 weeks old, were given a<br />
limited amount of diet (4 g per rat) overnight to reduce<br />
their stomach contents. The following day they were given<br />
500, 1000, 1500 or 2660 mg ammonium sulfate/kg bw in a<br />
volume of 0.5-1 mL by stomach tube.<br />
Ornithine decarboxylase activity (ODC) was measured in<br />
duplicate assays on pooled pyloric mucosa material from four<br />
rats 8 h after dosage. ODC activity was determined using<br />
L-(1-14C)-ornithine as a substrate. DNA synthesis in the<br />
pyloric mucosa of the stomach was determined in in vitro<br />
culture.<br />
Reliability: (2) valid with restrictions<br />
limited documentation<br />
Flag:<br />
Critical study for SIDS endpoint<br />
10-APR-<strong>20</strong>06 (147)<br />
Species: Syrian hamster Sex: male<br />
Route of administration: inhalation<br />
Exposure period:<br />
15 weeks<br />
Frequency of treatment: 6 hours/day, 5 days/week<br />
Post exposure period: 2 years<br />
Doses:<br />
186.6 ug ammonium sulfate/m3 (analytical) [<strong>20</strong>0 ug/m3<br />
(nominal)]<br />
Result:<br />
negative<br />
Control Group:<br />
other: BaP ( 5 mg i.tr.), once a week<br />
Method:<br />
other: see Test Condition<br />
Year: 1978<br />
GLP:<br />
no<br />
Test substance: other TS: ammonium sulfate, not further specified<br />
Remark:<br />
Result:<br />
The study evaluated the influence of ammonium sulfate as a<br />
cofactor in carcinogenesis studies employing benzo(a)pyrene<br />
as the prime agent. The study was repeated with the same<br />
concentration and animal number. The dose of ammonium sulfate<br />
tested was select as a conservative extrapolation of known<br />
sulfate levels of major metropolitan areas (3 fold dose).<br />
Additional information concerning influence on a metabolic<br />
enzyme (aryl hydroxylase) and the body`s absorption and<br />
excretion of sulfate was also included (cf IUCLID section on<br />
toxicokinetics).<br />
NOTE: wrong units (mg instead of ug) were used in some parts<br />
of the publication by Godleski et al., 1984.<br />
Exposure to ammonium sulfate resulted in a significant<br />
depression (p < 0.05) of benzo(a)pyrene (B(a)P)<br />
carcinogenesis in the first 6 months of the study. At<br />
termination of the study, however, there were no differences<br />
in cancer incidence between groups receiving B(a)P and B(a)P<br />
plus ammonium sulfate. In addition, at the concentration<br />
studied, inhaled ammonium sulfate alone did not significantly<br />
increase the incidence or severity of pneumonitis or pulmonary<br />
fibrosis in the hamster. This inhalation did increase the<br />
incidence of emphysema (16.1 vs 8.6%) but not the severity.<br />
UNEP PUBLICATIONS 195
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