AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Species:
Strain:
Sex:
Doses:
Exposure time:
Value:
guinea pig
no data
no data
500-900 mg/m3, average particle size 1-3 um
8 hour(s)
> 900 mg/m³
Method:
GLP:
Test substance:
other: see Test Condition
no data
other TS: ammonium sulfate, not further specified
Remark:
maximum attainable concentration of ammonium sulfate using
the equipment and methods available were used.
Result:
8/20 guinea pigs exposed to 800-900 mg/m3, 1/6 exposed to
600-700 mg/m3 and 0/6 exposed to 500-600 mg/m3 died during
exposure. The authors gave acute shock and airway
constriction as explanation for this effect. After exposure,
the survivors recovered with no noticeable after effects.
Test condition: Twenty guinea pigs were exposed (whole body) for a single
8-hours period to a concentration of 800-900 mg/m3, six to a
concentration of 600-700 mg/m3, and six to a concentration of
500-600 mg/m3. The animals were observed for mortality and
signs of gross toxicity.
Ammonium sulfate aerosol was generated from an aqueous
solution with Retec nebulizers and dried by mixing with dry
air and passing it through a heated glass tube. Ammonium
sulfate concentration was determined by collecting the
aerosol on a glass fiber filter at a flow rate of 2 L/min
for 15 minutes and weighing the filter. Accuracy of the
method was periodically checked by chemical analysis of the
filter sample. Particle size was evaluated gravimetrically
using an Andersen multi-stage sampler.
Reliability: (2) valid with restrictions
limited documentation, no information on purity, particle size
distribution not given
Flag:
Critical study for SIDS endpoint
10-APR-2006 (120)
Type:
Species:
Strain:
Sex:
Doses:
Exposure time:
GLP:
Test substance:
Result:
Test condition:
Reliability:
154
other: effect on pulmonary function
guinea pig
no data
no data
0.5 - 9.5 mg/m3, 4 groups
1 hour(s)
no
other TS: (NH4)2SO4, purity not stated
A slight increase in pulmonary flow resistance and a
statistically significant decrease in pulmonary compliance at
all concentrations and particle sizes tested was found. On a
scale in which the percentage increase in resistance caused by
0.3 um H2SO4 particles was assigned the value of "100",
ammonium sulfate was assigned a value of "10", i.e. a value
in-between NH4HSO4 (value of 3), and ZnSO4 (value of 19).
mass median diameter (MMD): 0.1 - 0.8 um.
10 animals per group
(2) valid with restrictions
no information on purity, no common test system
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