AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Result:
No mortality after 8 hours exposure (end of study).
No clinical signs reported.
No pathological findings at necropsy.
Test condition: According to "Description of methods use in BASF acute
toxicity and skin/eye irritation studies before pertinent
OECD/EU test guidelines were in place" (BASF AG, 2002).
12 rats were exposed for 8 hours to air saturated with the
vapor of the test substance at 20 °C. To generate the
saturated atmosphere, air was blown through a 5 cm layer of
the test substance. Necropsy was performed on all rats at
study end.
Reliability: (3) invalid
limited documentation, test system unsuitable for solid
substances
08-DEC-2003 (111)
Type:
Species:
Strain:
Sex:
Doses:
Exposure time:
other: effect on the rat respiratory defense system
rat
Sprague-Dawley
male
3.6 mg/m3 (MMAD: 0.4µm)
4 hour(s)
Method:
other
Year: 1980
GLP:
no data
Test substance: other TS: ammonium sulfate
Result:
Ammonium sulfate at high or low humidity did not have any
significant effects on early or late clearance compared to
that in low-humidity clear-air controls.
Test condition: 10-12 rats inhaled 3.6 mg/m3 (0.4 µm) ammonium sulfate as
aerosol for 4 hours (in low relative humidity 39 % and high
humidity 85%).
Reliability: (2) valid with restrictions
Flag:
Critical study for SIDS endpoint
10-APR-2006 (116)
Species:
Strain:
Sex:
Doses:
Exposure time:
Method:
GLP:
Test substance:
Result:
mouse
CD-1
female
5 exposure levels, up to 5.3 mg/m3
3 hour(s)
other: see Test Conditions
no
other TS: (NH4)2SO4, purity not stated
Inhalation of ammonium sulfate had little or no effect on
mice in this respiratory infection model in concentrations
up to 5.3 mg/m3 (highest tested exposure level). In
contrast, inhalation of zinc sulfate (1.2 mg/m3) resulted in
significant increases in mortality and reduced survival
time.
Mortalities (ammonium sulfate study):
control 233/588 (39.8%, mean survival time 10.1 d),