AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Species:
Route of administration:
other: cattle and sheep
oral
Remark:
In the latter part of 1991 an unusual neurological disease was
recognised on several farms in England. This report describes
the case histories and clinical, biochemical and pathological
findings in six calves and two lambs aged from two to 44 weeks
obtained from five of these farms. Laminar cerebrocortical
necrosis and severe bilateral necrosis of the thalamus and/or
striatum progressing to cavitation were recognised in the
brains. These changes are similar to those of experimental
sulphate toxicity. Morbidity rates of 16 to 48% and mortality
rates of 0 to 8 % were recorded. The affected animals did not
respond to vitamin B1 treatment; the erythrocyte transketolase
levels of in-contact cattle and one untreated calf and one
untreated lamb were within the normal range. All five farms
had recently introduced a proprietary concentrate ration
containing ammonium sulfate rather than the normal urinary
acidifier ammonium bicarbonate. After this ration was
withdrawn no new cases of nervous clinical disease were
observed. It is suggested that, in at least some cases, the
morphology and topography of lesions may distinguish sulfate
induced polioencephalomalacia from that of sporadic
thiamine-dependent cerebrocortical necrosis.
Reliability: (3) invalid
no common test system
10-APR-2006 (159) (160)
Endpoint:
Species:
other: effect of ammonium sulfate on absorption
sheep
Remark:
The experiment was conducted to study the relative effects of
sudden doses of urea and ammonium sulfate. The study evaluates
urea and ammonium sulfate as separate and combined sources of
nonprotein nitrogen in mature ewes and feedlot lambs.
Result:
Conclusion:
The data indicate that ammonia absorption is less rapid when
ammonium sulfate is added to the rumen than when an
isonitrogenous quantity of urea is administered.
In this experiment, 9.3 g of urea nitrogen per 100 lb of bw
when given as a drench resulted in two of three ewes dying of
ammonia toxicity compared with no toxic symptoms when
identical doses of nitrogen were given as ammonium sulfate.
The effect of administering urea and ammonium sulfate in
combination was similar to a mathematical average of the
effects observed when urea and sodium sulfate were
administered alone.
Reliability: (3) invalid
no common test system
10-APR-2006 (161)
Endpoint:
Neurotoxicity
Species:
rat
Strain: other: Lewis Sex:
Route of administration: intrafascicular
UNEP PUBLICATIONS 207