AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
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OECD SIDS<br />
<strong>AMMONIUM</strong> <strong>SULFATE</strong><br />
5. TOXICITY ID: <strong>7783</strong>-<strong>20</strong>-2<br />
DATE: 18.04.<strong>20</strong>06<br />
Strain: New Zealand white Sex:<br />
Result:<br />
The response of respiratory region clearance depend on total<br />
exposure, i.e., some combination form of c x t and was also<br />
related to relative acidity when H2SO4, NH4HSO4 and ammonium<br />
sulfate were investigated. Ammonium sulfate exposure (2 mg/m2)<br />
to 5 rabbits for 2h per day for 14 days resulted in no<br />
statistically significant change in clearance. Respiratory<br />
region clearance was measured by evaluating the retention of<br />
85 Sr-tagged polystyrene latex microspheres (3.5 um MMAD) by<br />
daily profile scanning.<br />
Reliability: (2) valid with restrictions<br />
No standard study, but well documented<br />
Flag:<br />
Critical study for SIDS endpoint<br />
16-JUL-<strong>20</strong>04 (169)<br />
Endpoint:<br />
Cytotoxicity<br />
Remark:<br />
Cytotoxicity of ammonium sulfate in aqueous medium was<br />
tested in different mammalian cell lines (HeLa, mouse<br />
lymphoma (ML) and Buffalo green monkey (BGM) cell lines).<br />
The percentage of survival at nominal concentrations of 1 ug<br />
NH3-N/mL was 76, 65 and 66% for HeLa, BGM and ML,<br />
respectively. The survival rate at 0.5 ug NH3-N/mL<br />
was 84, 79 and 84%. Buffalo green monkey cell line (derived<br />
from a non tumor tissue) was more sensitive than the tumor<br />
derived cell lines. The authors concluded that ammonium<br />
sulfate was not severely toxic to the cell lines tested.<br />
Reliability: (4) not assignable<br />
insufficient information to allow assessment of reliability<br />
10-APR-<strong>20</strong>06 (170)<br />
Endpoint:<br />
other: the effect on clearance from respiratory<br />
region or lung<br />
Result:<br />
In rats, the clearance of radioactively labeled insoluble<br />
particles was not influenced by exposure to ammonium sulfate<br />
(3.6 mg/m3; MMAD 0.4 um) at low (30-40%) or high (>80%)<br />
relative humidities for 4 hours. Exposure to both H2SO4<br />
(MMAD 1.0 um) and Fe2(SO4)3 (MMAD 0.4 um) significantly<br />
retarded clearance during a period of 2 to 17 days after<br />
exposure at low, but not high relative humidity.<br />
Reliability: (2) valid with restrictions<br />
no standard study<br />
14-JUN-<strong>20</strong>04 (116)<br />
Endpoint: other: subchronic exposure to a mixture of O3, S02,<br />
and Ammonium sulfate on host defenses of mice<br />
Species:<br />
mouse<br />
Strain: CD-1 Sex:<br />
Remark:<br />
210<br />
Mice exposed 5h/d, 5d/wk up to 103 d, to 0.2 mg ozone/m3, or<br />
to a mixture of ozone, 13.2 mg SO2/m3, and 1.04 mg Ammonium<br />
sulfate aerosol/m3 showed no significantly greater<br />
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