AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
effects were observed. When compared to controls, birth weight
was significantly increased.
All of the confirmed teratogens, also tested in the study did
decrease the live-born litter size.
Test condition: Aqueous sodium sulfate was given by gavage to 28 pregnant ICR
mice at a dose of 2800 mg/kg bw/day from gestation days 8
through 12.
A single dose level, at or near the level producing overt
maternal toxicity in preliminary range-finding studies with
non-pregnant animals was administered. Females were allowed to
deliver; litter size and weight on the day of birth and 2 days
postpartum were recorded, and stillborns were examined
macroscopically.
Reliability: (2) valid with restrictions
limited documentation, short exposure period, fetuses were not
examined histopathologically
Flag:
Critical study for SIDS endpoint
14-JUN-2004 (152)
Species: hen Sex:
Strain:
Leghorn
Route of administration: other: injection into the air cell of the egg
Exposure period:
single injection at the start of incubation
Doses: 10 mg/egg as aqueous ammonium sulfate (maximum 100
uL/egg)
Control Group:
no data specified
Result:
No adverse effects were reported for ammonium sulfate
Method:
other: see Test Condition
Year: 1980
GLP:
no data
Test substance: other TS: ammonium sulfate, aqueous solution
Test condition: In a screening teratogenicity study up to 10 mg/egg of
aqueous ammonium sulfate was injected (maximum 100 uL/egg)
into the air cells of the eggs at the start of
preincubation. The LD50 value was determined to be 4.63
mg/egg. Non viable embryos and hatched chicks were examined
for gross abnormalities and signs of toxicosis (such as
edema and hemorrhage). In a limited number of animals
examination of the viscera was performed and animals with
malformations that could not be readily classified were
further assessed by X-ray examination or Alizarin Red S
staining.
Reliability: (3) invalid
no approved test system
08-DEC-2003 (153)
Species: pig Sex:
Exposure period: from pre-breeding day 30 through lactation day 28
Doses:
1790, or 3298 mg/L sodium sulfate
Control Group:
yes, concurrent vehicle
Method:
GLP:
Test substance:
Result:
other: see Test Condition
no data
other TS: sodium sulfate, analytical grade
Sulfate content of water consumed during gestation had no
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