Handbook of Solvents - George Wypych - ChemTech - Ventech!

996 Michel Bauer, Christine Barthélémy
pyridine, tetrahydrofuran and dimethyl sulphoxide. Parsons and Col 39 have performed a
search for trace impurities in solvents commonly used for gas chromatographic analysis of
environmental samples.
14.21.1.5.3 Quality of solvents used in titrimetry
For titrimetric determinations performed in an aqueous medium it is highly recommended
to use distilled water and to perform a blank determination if necessary.
For determinations performed in non aqueous media, the solvents should be as anhydrous
as possible and, of course, inert to the titrant and the substance. Their purity should be
such that they do not contain impurities which could react with the substance to be analyzed.
A blank titration should be performed if necessary.
14.21.1.6 Conclusions
Far from being inert and not affecting the molecules dissolved in it, the solvent can affect
the behavior of the solute in different ways. This chapter has aimed to support the idea that it
is important for the chemist and the pharmacist to control the quality of the solvents used in
the different areas of pharmaceutical activity. As we have tried to show, many pitfalls can
be avoided during the development of a drug if a thorough investigation of the quality of the
solvents used is carried out.
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