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Handbook of Solvents - George Wypych - ChemTech - Ventech!

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16.2 Residual solvents in pharmaceutical substances 1141<br />

Figure 16.2.3. Typical chromatogram <strong>of</strong> class 1 solvents using the conditions described for system A and procedure<br />

1. Flame-ionization detector. 4: benzene; 10: carbon tetrachloride; 14: 1,2-dichloroethane; 15:<br />

1,1-dichloroethylene; 52: 1,1,1-trichloroethane. [Adapted, by permission, from European Pharmacopoeia, Addendum<br />

2000, pp31-36.] [Please note that information concerning residual solvents are susceptible to be modified<br />

in the successive editions <strong>of</strong> the European Pharmacopeia.]<br />

Figure 16.2.4. Chromatogram <strong>of</strong> class 2 solvents using the conditions described for system A and procedure 1.<br />

Flame-ionization detector. 3: acetonitrile; 11: chlor<strong>of</strong>orm; 13: cyclohexane; 16a: cis-1,2dichloroethylene; 17: dichloromethane;<br />

29: hexane; 30: 2-hexanone; 34: methanol; 49: pyridine; 51: toluene; 53: 1,1,2-trichloroethylene;<br />

54: xylene ortho, meta, para; 58: chlorobenzene; 61: tetraline; 62: methylcyclohexane: 63; nitromethane; 64:<br />

1,2-dimethoxyethane. [Adapted, by permission, from European Pharmacopoeia, Addendum 2000, pp31-36.]<br />

[Please note that information concerning residual solvents are susceptible to be modified in the successive editions<br />

<strong>of</strong> the European Pharmacopeia.]

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