Handbook of Solvents - George Wypych - ChemTech - Ventech!

15.2.1 Use of breath monitoring 1093
Alveolar ventilation Inhaled air available for gas exchange in 1 min
Anatomical dead space Volume (~150 mL) of conducting airways where no gas exchange occurs
BEI Biological Exposure Index. Reference value developed by ACGIH
Blood/air partition coefficient Ratio of the vapor concentration in blood and in air at 37 o C
Breathing frequency 15 breaths per minute at rest, increases with physical exertion
Conductive zone of lungs First segment of the airways, which includes the trachea, bronchi, terminal
bronchioles
End-exhaled air Operationally defined as the last portion of an exhalation to simulate alveolar
air
Exhaled air volume Approx. 500 mL at rest, increases with workload
GC-MS Gas Chromatography Mass Spectrometry
Minute Volume Ventilation The volume of air exhaled in 1 min, approx. 7,500 mL
Mixed-exhaled air Entire volume of exhaled air collected from alveolar space and anatomically
dead space
Respiratory zone Consists of respiratory bronchioles and alveolar ducts where gas exchange
takes place. Approx. 2,500 mL
STEL Short-Term Exposure Limit. The concentration to which most workers may
be exposed continuously for a short period of time without adverse effects.
Issued by ACGIH
Tidal Volume Volume of exhaled air; ~500 mL at rest
TLV Threshold Limit Value. Airborne concentration of a substance to which most
workers may be exposed without adverse health effects. Established by
ACGIH and intended as guideline.
References
1 R Lauwerys, Industrial chemical exposure: Guidelines for biological monitoring. Biomedical
Publications. Davis, California, 1983.
2 ACGIH, American Conference of Governmental Industrial Hygienists: TLV, Threshold Limit Values and
Biological Limit Values. Cincinnati, Ohio, 1998.
3 I Astrand, Scand J Work Environ Health. 1, 199-218, 1975.
4 V Fiserova-Bergerova, J Vlach, JC Cassady, Br J Ind Med., 37, 42-49, 1980.
5 PJA Borm and B de Barbanson, J Occup Med. 30, 214-223, 1988.
6 PO Droz and MP Guillemin, J Occup Med., 28, 593-602, 1986.
7 ACGIH, American Conference of Governmental Industrial Hygienists, Documentation of Threshold Limit
Values and Biological Limit Values. Cincinnati, Ohio, 1991.
8 JB West, Respiratory Physiology - The essentials, The Williams & Wilkins Co., Baltimore, 1981.
9 AC Monster, W Regouin-Peeters, A van Schijndel, J van der Tuin, Scand J Work Environ Health, 9,
273-281, 1983.
10 V Fiserova-Bergerova, Modeling of inhalation exposure to vapors, Uptake, distribution and
elimination, CRC Press Inc., Boca Raton, Florida, 1983.
11 A Sato and T Nakajima, Brit. J. Ind. Med., 36, 231-234, 1979.
12 A Morgan, A Black, DR, Belcher, Ann Occup Hyg., 13, 219-233, 1970.
13 LE Farhi, Respir Physiol., 3, 1-11, 1967.
14 GR Kelman, Br J. Ind Med., 39, 259-264, 1982.
15 JE Cotes, Lung function, Assessment and application in medicine, Blackwell Scientific Publications,
Oxford, 1979.
16 J Widdicombe and A Davies, Respiratory physiology, Edward Arnold, London, 1983.
17 HK Wilson, Breath analysis, Scand J Work Environ Health, 12, 174-192, 1986.
18 V Fiserova-Bergerova, M Tichy, and FJ DiCarlo, Drug metabolism reviews, 15, 1033-1070, 1984.
19 KM Dubowski, Clin. Chem., 20, 966-972, 1974.
20 HC Niu, DA Schoeller, PD Klein, J Lab Clin Med., 91, 755-763, 1979.
21 M Guillemin and E Guberan, Br J Ind Med., 39, 161-168, 1982.
22 TA Robb TA and GP Davidson, Clinica Chimica Acta, 111, 281-285, 1981.
23 JS Haldane, and JG Priestley, J Physiol., 32, 225-266. 1905.
24 JH Raymer, KW Thomas, SD Cooper, DA Whitaker, ED Pellizzari, J Anal. Toxicol., 14, 337-344, 1990.
25 SM Rappaport, E Kure, MX Petreas, D Ting, J Woodlee, Scand. J. Work Envir. Health, 17, 195-204, 1991.