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Handbook of Solvents - George Wypych - ChemTech - Ventech!

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1340 Kristen I. McMartin, Gideon Koren<br />

for cohort studies was 1.73 (95% CI: 0.74 - 4.08) and 1.62 (95% CI: 1.12 - 2.35) for<br />

case-control studies.<br />

Table 20.3.2. Studies <strong>of</strong> spontaneous abortion <strong>of</strong> organic solvents meeting criteria for<br />

meta-analysis. [Adapted, by permission, from K.I. McMartin, M. Chu, E. Kopecky, T.R.<br />

Einarson and G. Koren, Am. J. Ind. Med., 34, 288 (1998) Copyright 1998 John Wiley &<br />

Sons, Inc.<br />

Sons, Inc.]<br />

Reprinted by permission <strong>of</strong> Wiley-Liss, Inc. a division <strong>of</strong> John Wiley &<br />

Authors Study type Data collection<br />

Windham et al. 21<br />

CC R<br />

Lipscomb et al. 22<br />

C R<br />

Shenker et al. 23<br />

C P<br />

Pinney 24<br />

C R<br />

Eskenazi et al. 25<br />

C P<br />

CC=Case control, C=Cohort, R=Retrospective, P=Prospective<br />

Table 20.3.3. Results <strong>of</strong> studies comparing outcomes <strong>of</strong> fetuses exposed or not<br />

exposed to organic solvents. [Adapted, by permission, from K.I. McMartin, M. Chu, E.<br />

Kopecky, T.R. Einarson and G. Koren, Am. J. Ind. Med., 34, 288 (1998) Copyright 1998<br />

John Wiley & Sons, Inc. Reprinted by permission <strong>of</strong> Wiley-Liss, Inc. a division <strong>of</strong> John<br />

Wiley & Sons, Inc.]<br />

Reference Exposure<br />

Axelsson et al. 16<br />

Tikkanen et al. 17<br />

Holmberg et al. 18<br />

Cordier et al. 19<br />

Lemasters 20<br />

TOTAL<br />

organic solvents yes<br />

no<br />

total<br />

organic solvents yes<br />

no<br />

total<br />

organic solvents yes<br />

no<br />

total<br />

organic solvents yes<br />

no<br />

total<br />

styrene yes<br />

no<br />

total<br />

yes<br />

no<br />

total<br />

Yes<br />

Congenital Defect<br />

No Total<br />

3<br />

4<br />

7<br />

23<br />

546<br />

569<br />

11<br />

1464<br />

1475<br />

29<br />

234<br />

263<br />

4<br />

13<br />

17<br />

70<br />

2261<br />

2331<br />

489<br />

492<br />

981<br />

26<br />

1026<br />

1052<br />

7<br />

1438<br />

1475<br />

22<br />

285<br />

307<br />

68<br />

822<br />

890<br />

612<br />

4100<br />

4712<br />

492<br />

496<br />

988<br />

49<br />

1572<br />

1621<br />

18<br />

2902<br />

2950<br />

51<br />

519<br />

570<br />

72<br />

835<br />

907<br />

682<br />

6354<br />

7036

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