LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) evidence approach. A robust summary for the study with the lowest LC50 value was prepared (see Lewis and Perry 1981 above). Reference: HERA-LAS team , May 2004; see SIAR, Annex 2. Reliability: 4 Not assignable. This study is given a reliability score of 4 because it is a summary evaluation of a series of studies conducted by other researchers. (c) Species: Lepomis macrochirus Results: LC50 = 3.0 mg/L (geometric mean of 88 records) Test Substance: C10-14 LAS (all LAS in range, including data for individual homologues) Remarks: Mean LC50 for bluegill sunfish was derived from a total of 88 records compiled from the BKH (1993) literature review. Reference: van de Plassche, E.J., de Bruijn, J.H.M., Stephenson, R.R., Marshall, S.J., Feijtel, T.C.J. and Belanger, S.E. 1999. Predicted no-effect concentrations and risk characterization of four surfactants: LAS, AE, AES, and soap, Environ. Toxicol. Chem. 18:2653-2663. Reliability: 4 This study was given a reliability score of 4 because the original reports reviewed by the authors were not directly reviewed in the compilation of this robust summary. (d) Species: Pimephales promelas Results: LC50 = 3.2 mg/L (geometric mean of 35 records) Test Substance: C10-14 LAS (all LAS in range, including data for individual homologues) Remarks: Mean LC50 for fathead minnow was derived from a total of 35 records compiled from the BKH (1993) literature review. The range of LC50 values (0.40-100 mg/L) is very large due to the range of materials tested (including many materials not representative of commercial LAS) and the differences in test design (not necessarily following standard guidelines). It is unclear which values within the range refer to the commercial LAS products and the individual records are not available for validation. Reference: van de Plassche, E.J., de Bruijn, J.H.M., Stephenson, R.R., Marshall, S.J., Feijtel, T.C.J. and Belanger, S.E. 1999. Predicted no-effect concentrations and risk characterization of four surfactants: LAS, AE, AES, and soap, Environ. Toxicol. Chem. 18:2653-2663. Reliability: 4 This study was given a reliability score of 4 because the original reports reviewed by the authors were not directly reviewed in the compilation of this robust summary. (e) Species: Leuciscus idus melanotus Results: LC50 = 2.9 mg/L (geometric mean of 11 records) Test Substance: C10-14 LAS (all LAS in range, including data for individual homologues) Remarks: Mean LC50 for golden orfe was derived from a total of 11 records compiled from the BKH (1993) literature review. Reference: van de Plassche, E.J., de Bruijn, J.H.M., Stephenson, R.R., Marshall, S.J., Feijtel, T.C.J. and Belanger, S.E. 1999. Predicted no-effect concentrations and risk characterization of four surfactants: LAS, AE, AES, and soap, Environ. Toxicol. Chem. 18:2653-2663. Reliability: 4 This study was given a reliability score of 4 because the original reports reviewed by the authors were not directly reviewed in the compilation of this robust summary. (f) Species: Carassius auratus (goldfish) UNEP PUBLICATIONS 176
OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) Oncorhynchus mykiss (rainbow trout) Oryzias latipes (medaka) Poecilia reticulata (guppy) Results: LC50 (C. auratus) = 9.5 mg/L (46 records) LC50 (O. mykiss) = 3.0 mg/L (10 records) LC50 (O. latipes) = 13 mg/L (5 records) LC50 (P. reticulata) = 3.8 mg/L (9 records) Test Substance: C10-14 LAS (all LAS in range, including data for individual homologues) Remarks: Geometric mean LC50 values for the number of records listed for each species. The interspecies variation decreases considerably when the geometric mean value per species is calculated. Reference: van de Plassche, E.J., de Bruijn, J.H.M., Stephenson, R.R., Marshall, S.J., Feijtel, T.C.J. and Belanger, S.E. 1999. Predicted no-effect concentrations and risk characterization of four surfactants: LAS, AE, AES, and soap. Environ. Toxicol. Chem. 18:2653-2663. Reliability: 4 This study was given a reliability score of 4 because the original reports reviewed by the authors were not directly reviewed in the compilation of this robust summary. (g) Species: Fish species (all marine) Results: LC50 = 1.58 mg/L (6 records; SD = 0.16) Test Substance: LAS; average alkyl chain length C11.7-12.0 Remarks: LC50 is geometric mean of 6 records compiled from literature reviews. Geometric mean LC50 for all taxa (36 records; SD = 0.79) was 4.36 mg/L. Reference: Temara, A., Carr, G., Webb, S., Versteeg, D., and Feijtel, T.C.J. 2001. Marine risk assessment: Linear alkylbenzensulphonates (LAS) in the North Sea. Mar. Poll. Bulletin 42:635-642. Reliability: 4 This study was given a reliability score of 4 because the original reports reviewed by the authors were not directly reviewed in the compilation of this robust summary. (h) (Zebra fish) Type of test: static [ ]; semi-static [ ]; flow-through [ X ]; other[ ] open-system [X]; closed-system [ ] Species: Brachydanio rerio (Fish, fresh water) Exposure period: 96 hour Results: LC50 = 5.1 mg/L Analytical monitoring: Yes [ ] No [X ] ? [ ] Method: OECD Guide-line 203 “Fish, Acute Toxicity Test” GLP: Yes [ ] No [ ] ? [X] Test substance: C10-13 LAS (CAS #68411-30-3) Remarks: Information as cited in IUCLID Data Sheet for CAS #68411-30-3. The submitter (Huels AG) judged the study quality to be good. Water hardness: 310 mg/L CaCO3; tap water diluent; 25 ºC; adult fish tested. Reference: European Commission. 2000f. Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts. Year 2000 CD-ROM edition, citing Procter & Gamble, 1991, AT/FU/80/90. Reliability: 4 Not assignable. The original study was not available for review. (i) Type of test: static [ ]; semi-static [X]; flow-through [ ]; other [ ] open-system [X]; closed-system [ ] Species: Brachydanio rerio (Fish, fresh water) Exposure period: 96 hour Results: LC50 = 7.8 mg/L UNEP PUBLICATIONS 177
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LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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