LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
(b)
Type: Guinea pig maximisation test
Species/strain: guinea pig, females
Results: Sensitising [ ]; Not sensitising [X]; Ambiguous [ ]
Classification: Sensitising [ ]; Not sensitising [X]
Method: OECD Guide-line 406 "Skin Sensitisation" 1981
GLP: Yes [ ] No [X] ? [ ]
Test substance: Marlon A 350 (CAS #68411-30-3) C10-13 LAS, average alkyl chain length =
C11.6; activity: 50%.
Remarks: 0.1% intracutaneous and 3% epidermal doses. No sensitizing effects were
observed.
Reference: Murmann, P. 1988. Prufung auf hautsensibilisierende Wirkung am
Meerschweinchen von Marlon A 350. Huels Report No. 1387.
Reliability: 2 Valid with restrictions
(c)
Type: Maximization test
Species/strain: Guinea pig, Hartley
Results: Sensitising [ ]; Not sensitising [X]; Ambiguous [ ]
Classification: Sensitising [ ]; Not sensitising [X]
Method: OECD Guideline 406, 1981; Directive 179/831 Annex, Part B.
GLP: Yes [X] No [ ] ? [ ]
Test substance: LAS, activity: 50%; average alkyl chain length = C11.6
Remarks: Solutions of LAS were applied intracutaneously and epicutaneously to 10
male and 10 female animals. Induction concentration was 25% in water; the
challenge concentration was 12.5%. No positive responses were observed.
Reference: RBM. 1985. Test di sensibilizzazione cutanea nella cavia. RBM Exp. No.
2076.
Reliability: 1 Valid without restriction
5.4 REPEATED DOSE TOXICITY
(a)
Species/strain: Rat (FDRL)
Sex: Female [ ]; Male [ ]; Male/Female [X]; No data [ ]
Administration: Oral feed
Exposure period: 12 weeks
Dose: 50 or 250 mg/kg bw d
Control group: Yes [X]; No [ ]; No data [ ];
Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ]
NOAEL: 50 mg/kg bw d
LOAEL: 250 mg/kg bw d
Results: No behavioural abnormalities were noted during the test period. Growth
responses were equal in all groups. There were no differences in food intake
or in efficiency of food utilization. The clinical data showed no abnormal
variations in any of the dose groups. The relative organ weights and the
histopathological evaluation did not show significant differences among the
dose groups except a liver weight increase in female animals of the high dose
group.
Method: Based on Fitzhugh and Schouboe (1959) Subacute toxicity in: Assoc. Food
Drug Offices of the U.S., Austin, Texas, p. 26-35. Weanling rats were
distributed into 5 groups of 15 male and 15 female animals per dose group.
All rats were given standard diet daily. Doses were 0, 50 and 250 mg/kg bw
d in the diet. Daily observations of behavior and signs of toxicity were made.
Food consumption and blood and urine chemistries were also measured
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