LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals
LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals
LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals
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OECD SIDS <strong>LINEAR</strong> <strong>ALKYLBENZENE</strong> <strong>SULFONATE</strong> (<strong>LAS</strong>)<br />
GLP: Yes [ ] No [X] ? [ ]<br />
Test substance: <strong>LAS</strong> (made from Sirene LAB); activity 5%; average alkyl chain length =<br />
C11.6<br />
Remarks: Average irritation scores were 0, 0, 1.83, and 1.16 for the cornea, iris,<br />
conjunctival redness, and conjunctival chemosis, respectively. This<br />
classifies <strong>LAS</strong> at 5% as moderately irritating.<br />
Reference: Biolab SGS. 1988. Acute eye irritation. Report No. T343.<br />
Reliability: 2 Valid with restrictions<br />
(i)<br />
Species/strain: albino male and female rabbits<br />
Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ];<br />
Irritating [ ]; Moderate irritating [X]; Slightly irritating [ ];<br />
Not irritating [ ]<br />
Classification: Irritating [X]; Not irritating [ ]; Risk of serious damage to eyes [ ]<br />
Method: A total of 100 mg of finely ground sample was administered in the<br />
conjunctival sac of the right eye of each of six albino male and female<br />
rabbits. Observations for inflammation were made over seven days. The<br />
treated eyes were washed with sodium chloride solution USP after the 24<br />
hour reading. The left eye served as a control. The data was scored<br />
according to the method of Draize, et al. Tests were conducted in accordance<br />
with the Federal Hazardous Substance Act.<br />
GLP: Yes [ ] No [X] ? [ ]<br />
Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-225) C9 1%, C10 7%, C11<br />
25%, C12 48%, C13 19%, C14 1%; average alkyl chain length = C11.9<br />
Remarks: The compound is classified as an eye irritant under the grading system as<br />
outlined in the Federal Hazardous Substances Act. Slight to moderate<br />
erythema was present after 10 minutes and persisted through 72 hours.<br />
Edema was present after 1 hour and persisted through 24 hours. The average<br />
maximum irritation score was 19.3 out of a possible 110.<br />
Reference: Monsanto Company. 1971. Linear alkylbenzene sodium sulfonate –<br />
Alkylate 225 Lot CC 6450 – Acute toxicity screen. Project No. Y-71-119.<br />
Unpublished report.<br />
Reliability: 2 Valid with restrictions<br />
(j)<br />
Species/strain: albino male and female rabbits<br />
Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ];<br />
Irritating [ ]; Moderate irritating [ ]; Slightly irritating [X];<br />
Not irritating [ ]<br />
Classification: Irritating [X]; Not irritating [ ]; Risk of serious damage to eyes [ ]<br />
Method: A total of 100 mg of finely ground sample was administered in the<br />
conjunctival sac of the right eye of each of three albino male and female<br />
rabbits. Observations for inflammation were made over seven days. The<br />
treated eyes were washed with isotonic saline solution after the 24 hour<br />
reading. The left eye served as a control. The data was scored according to<br />
the method of Draize, et al. Tests were conducted in accordance with the<br />
Federal Hazardous Substance Act.<br />
GLP: Yes [ ] No [X] ? [ ]<br />
Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-215) C9 1%, C10 16%, C11<br />
43%, C12 40%, C13 1%, C14
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