LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) (c) Type: Dominant lethal assay Species/strain: mouse (ICR: JCL) Sex: Female [ ]; Male [X]; Male/Female [ ]; No data [ ] Administration: oral feed Exposure period: 9 months Doses: 0.6% (300 mg/kg bw d) Results: There were no significant differences in fertility, the mortality of ova and embryos, the number of surviving fetuses, or the index of dominant lethal induction between the experimental groups and the control group. Method: Seven male mice received LAS in the diet for 9 months. Each of the male mice was then mated with 2 female mice that had not been given LAS. The pregnant mice were laparotomized on day 13 of gestation to determine the numbers of luteal bodies, implantations, surviving fetuses, and dead fetuses. GLP: Yes [ ] No [X] ? [ ] Test substance: LAS Remarks: Information as cited in the IPCS document. Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts. Year 2000 CD-ROM edition. 2) Masabuchi, M., Takahashi, A., Takahashi, O. and Hiraga, K. 1976. Cytogenetic studies and dominant lethal tests with long term administration of butylated hydroxytoluene (BHT) and linear alkylbenzene sulfonate (LAS) in mice and rats. Ann. Rep. Tokyo Metrop. Res. Lab. Public Health. 27:100- 104 (in Japanese); cited in: IPCS (1996); Environmental Health Criteria 169: Linear Alkylbenzene Sulfonates (LAS) and Related Compounds. WHO, Geneva, Switzerland. Reliability: 4 This study is assigned a reliability score of 4 because the original report was not available for review. However, the study was evaluated by IPCS prior to inclusion in their criteria document. (d) Type: Micronucleus assay Species/strain: mouse: (ddy) Sex: Female [ ]; Male [X]; Male/Female [ ]; No data [ ] Administration: Intraperitoneal injection Exposure period: single dose Doses: 100 mg/kg bw Results: There were no differences in the incidences of polychromatic erythrocytes with micronuclei in the bone marrow cells between the treated group and the control group. Method: Three male ddy mice were each given a single i.p. injection of 100 mg/kg bw LAS. GLP: Yes [ ] No [X] ? [ ] Test substance: LAS Remarks: Information as cited in the IPCS document. Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts. Year 2000 CD-ROM edition. 2) Kishi, M., Satoh, S., Horiguchi, Y. and Ito, K. 1984. Effects of surfactants on bone marrow cells. Bull. Kanagaw Public Health Lab. 14:57-58. (In Japanese); cited in: IPCS (1996); Environmental Health Criteria 169: Linear Alkylbenzene Sulfonates (LAS) and Related Compounds. WHO, Geneva, Switzerland. UNEP PUBLICATIONS 284
OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) Reliability: 4 This study is assigned a reliability score of 4 because the original report was not available for review. However, the study was evaluated by IPCS prior to inclusion in their criteria document. 5.7 CARCINOGENICITY (a) Species/strain: Rat: Charles River Sex: Female [ ]; Male [ ]; Male/Female [X]; No data [ ] Administration: oral feed Exposure period: 2 years Frequency of treatment:continuous in feed Doses: 0.02, 0.1, 0.5% (10, 50, 250 mg/kg bw d) Control group: Yes [X]; No [ ]; No data [ ]; Concurrent no treatment [ X]; Concurrent vehicle [ ]; Historical [X] Results: Gross examination of all animals for pathology did not reveal any abnormalities. No consistent dietary induced changes that could be considered a toxic response were observed. Animals that showed significant loss of weight, development of tumors, or other evidence of abnormalities were sacrificed and tissues examined. The incidence of tumors and the common incidental diseases were similar in all dieting groups. Method: Four groups of Charles River weanling rats, divided by sex, were given 0.5, 0.1, and 0.02% LAS in their food for 2 years. Following completion of those studies, five male and five female rats from each of the parental groups (F1b and F2b) and all survivors were selected for necropsy. Body weight and organ to body weight ratios were recorded, and routine hematology and histology were performed. Weanling animals for the F3a generation were similarly treated. GLP: Yes [ ] No [X] ? [ ] Test substance: C10-14 LAS; activity: 98.1% on an anhydrous basis (41.9% active) Reference: Buehler, E.V., Newmann, E.A., and King, W.R. 1971. Two year feeding and reproduction study in rats with linear alkylbenzene sulfonate (LAS). Toxicol. Appl. Pharmacol. 18:83-91. Reliability: 2 Valid with restrictions (b) Species/strain: Rat/Wistar Sex: Female [ ]; Male [X]; Male/Female [ ]; No data [ ] Administration: Drinking water Exposure period: 2 years Frequency of treatment: Daily Doses: 0.01%, 0.05%, 0.1% (20,100, 200 mg/kg bw d) Control group: Yes [X]; No [ ]; No data [ ]; Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ] Results: There were no changes due to the administration of LAS in regard to growth, mortality, the weight of major organs, or histopathological findings. The intake of LAS was about 200 mg/kg bw d in the 0.1% group. There is no description of tumors. Method: Groups of 20 male Wistar rats were given LAS in drinking water daily for 2 years. GLP: Yes [ ] No [X] ? [ ] Test substance: LAS, activity: 34.55% Remarks: Information as cited in the IPCS document. Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts. Year 2000 CD-ROM edition. UNEP PUBLICATIONS 285
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LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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