LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Exposure period: from day 6 through day 15 of pregnancy
Frequency of treatment: daily
Doses: 0.03, 0.3, 3% (15, 150, and 1500 mg/kg bw d)
Control group: Yes [X]; No [ ]; No data [ ];
Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ]
NOAEL Maternal: 0.3% (150 mg/kg bw d)
NOAEL teratogenicity: 3% (1500 mg/kg bw d)
Results: The 3% group showed a clear decrease in the pregnancy rate (67.9%) when
compared with a rate of 96.3% in the controls. However, there were no
decreases in the litter size, and no changes in the litter parameters with the
exception of a slight decrease in fetal body weight. There were no significant
increases in the incidence of malformations in the fetuses.
Method: Areas of 4 x 4 cm on the backs of the mice were depilated and aqueous
solutions of LAS were applied.
GLP: Yes [ ] No [X] ? [ ]
Test substance: C10-14 LAS (CAS #69669-44-9); average alkyl chain length (based on LAS
SIDS Consortium Survey, 2002) = C11.7; activity: 46.6%
Remarks: Information as cited in the IUCLID Data Sheet and the IPCS document.
Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs.,
sodium salts. Year 2000 CD-ROM edition.
2) Imahori, A., Kinagawa, T. and Shiobara, S. 1976. Effects of linear alkyl
benzene sulfonate (LAS) applied dermally to pregnant mice and their fetuses.
Jpn. J. Public Health. 23:68-72 (in Japanese); cited in IPCS (1996);
Environmental Health Criteria 169: Linear Alkylbenzene Sulfonates (LAS)
and Related Compounds. WHO, Geneva, Switzerland.
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document.
(q)
Species/strain: mouse/ICR
Sex: Female [X]; Male [ ]; Male/Female [ ]; No data [ ]
Administration: Subcutaneous injection
Exposure period: Day 0 to 3 or day 8 to 11 of pregnancy
Frequency of treatment: daily
Doses: 0.35, 1% in water (20, 200 mg/kg bw d)
Control group: Yes [X]; No [ ]; No data [ ];
Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ]
NOAEL Maternal: 0.35% (20 mg/kg bw d)
NOAEL teratogenicity : 1% (200 mg/kg bw d)
Results: When dams were administered the 1% solution from day 0 to 3 of pregnancy,
there was an initial decrease in body weight and necrosis at the injection
sites. The number of pregnancies decreased in the mice given the 1%
solution compared to the controls (61.5% vs. 93.3%) There were no
significant changes with respect to litter parameters, major malformations or
minor abnormalities.
Method: LAS was injected at doses of 20 mL/kg/day from day 0 to 3 or day 8 to 11 of
pregnancy. There were 12 - 19 mice in each treatment group.
GLP: Yes [ ] No [X] ? [ ]
Test substance: LAS, activity: 99.5%
Remarks: Information as cited in the IUCLID Data Sheet and the IPCS document.
Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs.,
sodium salts. Year 2000 CD-ROM edition.
2) Takahashi, M., Sato, K., Ando, H., Kubo, Y. and Hiraga, K. 1975.
Teratogenicity of some synthetic detergents and linear alkylbenzene sulfonate
(LAS) Ann. Rep. Tokyo Metrop. Res. Lab. Public Health 26:67-78 (in
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