LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
individual cages. Observations of toxic signs were recorded daily and the
viscera of the test animals were examined macroscopically.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-215; C9 1%, C10 16%, C11
43%, C12 40%, C13 1%, C14 631 mg/kg and < 1000 mg/kg
Method: Acute Skin Absorption Minimal Lethal Dose Test
The test substance was applied as a 20% aqueous solution and the doses of
the solution administered were 200, 398, 631, 1000, 1260, 2000 and 3160
mg/kg. The doses were administered to a closely clipped area of intact skin
of male and female rabbits (1 animal/dose). The treated areas were covered
with plastic strips and the animals were placed in wooden stocks for up to
twenty-four hours. After the twenty-four hours the animals were assigned to
individual cages. Observations of toxic signs were recorded daily and the
viscera of the test animals were examined macroscopically.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-222L; average alkyl chain
length = C11.5)
Remarks: The test substance was classified as moderately toxic. Survival time was two
days. The toxic signs were reduced appetite and activity, increasing
weakness, collapse and death. The autopsy revealed lung hyperemia, areas
of liver discoloration and gastrointestinal inflammation. The animals that
survived were sacrificed fourteen days after dosing. In these animals the
viscera appeared normal by macroscopic examination.
Reference: Monsanto Company. 1972b. Linear alkylbenzene sodium sulfonate –
Alkylate 222L Lot CC 6773S – Acute toxicity screen. Project No. Y-72-275.
Unpublished report.
Reliability: 4 (insufficient animals per dose of mixed sex, etc.)
5.1.4 ACUTE TOXICITY, OTHER ROUTES OF ADMINISTRATION
(a)
Type: LD0 [ ]; LD100 [ ]; LD50 [X]; LDL0 [ ]; Other [ ]
Species/strain: rat
Administration: i.m. [ ]; i.p. [ ]; i.v. [ ]; infusion [ ]; s.c. [X]; other [ ]
Value: Females = 810 mg/kg; males = 840 mg/kg bw
Method: Rats were given subcutaneous injections of LAS
GLP: Yes [ ] No [X] ? [ ]
Test substance: C10-13 LAS, sodium salt (CAS #68411-30-3)