LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) individual cages. Observations of toxic signs were recorded daily and the viscera of the test animals were examined macroscopically. GLP: Yes [ ] No [X] ? [ ] Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-215; C9 1%, C10 16%, C11 43%, C12 40%, C13 1%, C14 631 mg/kg and < 1000 mg/kg Method: Acute Skin Absorption Minimal Lethal Dose Test The test substance was applied as a 20% aqueous solution and the doses of the solution administered were 200, 398, 631, 1000, 1260, 2000 and 3160 mg/kg. The doses were administered to a closely clipped area of intact skin of male and female rabbits (1 animal/dose). The treated areas were covered with plastic strips and the animals were placed in wooden stocks for up to twenty-four hours. After the twenty-four hours the animals were assigned to individual cages. Observations of toxic signs were recorded daily and the viscera of the test animals were examined macroscopically. GLP: Yes [ ] No [X] ? [ ] Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-222L; average alkyl chain length = C11.5) Remarks: The test substance was classified as moderately toxic. Survival time was two days. The toxic signs were reduced appetite and activity, increasing weakness, collapse and death. The autopsy revealed lung hyperemia, areas of liver discoloration and gastrointestinal inflammation. The animals that survived were sacrificed fourteen days after dosing. In these animals the viscera appeared normal by macroscopic examination. Reference: Monsanto Company. 1972b. Linear alkylbenzene sodium sulfonate – Alkylate 222L Lot CC 6773S – Acute toxicity screen. Project No. Y-72-275. Unpublished report. Reliability: 4 (insufficient animals per dose of mixed sex, etc.) 5.1.4 ACUTE TOXICITY, OTHER ROUTES OF ADMINISTRATION (a) Type: LD0 [ ]; LD100 [ ]; LD50 [X]; LDL0 [ ]; Other [ ] Species/strain: rat Administration: i.m. [ ]; i.p. [ ]; i.v. [ ]; infusion [ ]; s.c. [X]; other [ ] Value: Females = 810 mg/kg; males = 840 mg/kg bw Method: Rats were given subcutaneous injections of LAS GLP: Yes [ ] No [X] ? [ ] Test substance: C10-13 LAS, sodium salt (CAS #68411-30-3)
OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) Remarks: Information as cited in IPCS document. Reference: Ito, R., Kawamura, H., Chang, H.S., Kudo, K., Kajiwara, S., Toida, S., Seki, Y., Hashimoto, M., and Fukushima, A. 1978. Acute, subacute and chronic toxicity of magnesium linear alkylbenzene sulfonate (LAS-Mg). J. Med. Soc. Toho, Japan. 25 (5-6):850-875 (in Japanese). Referenced in IPCS, Environmental Health Criteria 169. Linear Alkylbenzene Sulfonates and Related Compounds. Reliability: 4 This study is assigned a reliability score of 4 because the original report was not available for review. However, the study was evaluated by IPCS prior to inclusion in their criteria document. (b) Type: LD0 [ ]; LD100 [ ]; LD50 [X]; LDL0 [ ]; Other [ ] Species/strain: mouse Administration: i.m. [ ]; i.p. [ ]; i.v. [ ]; infusion [ ]; s.c. [X]; other [ ] Value: Females = 1400 mg/kg; males = 1250 mg/kg bw Method: Mice were given subcutaneous injections of LAS. GLP: Yes [ ] No [X] ? [ ] Test substance: C10-13 LAS, sodium salt (CAS #68411-30-3)
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LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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