LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Administration: gavage
Duration of the test: sacrifice at day 20 of gestation
Exposure period: day 6 - 15 of pregnancy
Frequency of treatment:daily
Doses: 0.2, 2, 300, 600 mg/kg bw d
Control group: Yes [X]; No [ ]; No data [ ];
Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ]
NOAEL Maternal
Toxicity: 300 mg/kg bw
NOAEL teratogenicity: 600 mg/kg bw
Results: Maternal toxicity:
Body weight gain was retarded in the highest dose group from the start of
dosing and showed partial recovery toward the end of the dosing period. One
animal died in this group but it could not be conclusively related to treatment.
The toxic effects were associated with disturbance of the gastrointestinal
tract. Pregnancy rate was comparable at all dosages.
Teratogenicity:
No differences were observed among dose groups and the control group with
respect to number of litters, viable young, litter weight, foetal weight,
embryonic deaths, implantations, corpora lutea, pre- and post implantation
embryonic loss, major malformations, minor visceral or embryonic loss,
major malformations, minor visceral or skeletal anomalies or incidence of
pups with extra ribs.
Method: Animals received doses by gavage daily from days 6-15 of gestation. Twenty
animals per dose group were used.
GLP: Yes [ ] No [X] ? [ ]
Test substance: LAS
Reference: Palmer, A.K., Readshaw, M.A. and Neuff, A.M. 1975a. Assessment of the
teratogenic potential of surfactants (Part I) – LAS, AS and CLD. Toxicology
3:91-106.
Reliability: 2 Valid with restrictions
(c)
Species/strain: Charles River CD strain rat
Sex: Female [X]; Male [ ]; Male/Female [ ]; No data [ ]
Administration: Oral in distilled water
Duration of the test: 20 days
Exposure period: day 6 to day 15 of pregnancy
Frequency of treatment:daily
Doses: 0.2, 2.0, 300 and 600 mg/kg
Control group: Yes [X]; No [ ]; No data [ ];
Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ]
NOAEL Maternal: 300 mg/kg
NOAEL teratogenicity: 300 mg/kg
Results: Maternal toxicity: Parent animals were observed daily. Change in
bodyweight was not affected by treatment at 0.2, 2.0, and 300 mg/kg, but
treatment at 600 mg/kg was associated with retarded weight gain and a
transient diarrhea following initiation of treatment. The pregnancy rate was
comparable at all dosages.
Pregnancy/litter data: The litter parameters assessed included litter size, fetal
loss and litter weight. These parameters were not significantly affected by
any dosage. Mean pup weights were statistically higher at 0.2, 2.0 and 300
mg/kg.
Teratogenicity: Embryonic and fetal development were assessed by the
incidence of major malformations. The incidence of minor visceral
anomalies was unaffected by treatment at any dosage. The distribution of
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