LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Results: The 0.6% group showed slight increases in the weight of liver and cecum,
and increased activity of GPT and ALP in serum. LAS administration had no
adverse effects upon the intake of food, body weight gain, general condition,
mortality or mean survival. At one month, proliferation of hepatic cells in the
liver and slight swellings of the renal tubes and narrowing of the tubular
lumen in the kidneys were found in the 0.16% and 0.6% groups. These
findings later disappeared, and are considered to be adaptation phenomena to
the administration of LAS. There were no histopathological lesions
attributable to LAS administration in any of the organs in rats fed for 24
months or more. Various types of tumors were observed in various organs,
but findings suggestive of tumorigenicity of LAS were not present.
Therefore, the authors concluded that the diet containing LAS at a
concentration of 0.6% (300 mg/kg bw d) did not have any adverse effects on
rats.
Method: Groups of 50 male and 50 female rats were given diets containing LAS at
0.04, 0.16 and 0.6%. In each group, 5 rats of each sex were fed for 1, 3, 6,
and 12 months, respectively, and groups of 15 rats of each sex were fed for
24 months or more. Detailed histopathological examinations were made on
the rats.
GLP: Yes [ ] No [X] ? [ ]
Test substance: C10-14 LAS; C10 10.6%, C11 34.1%, C12 27.7%, C13 19.0%, C14 8.7%; average
alkyl chain length = C11.8; mean molecular weight 345.8
Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs.,
sodium salts. Year 2000 CD-ROM edition.
2) Fujii, T., Sakamoto, Y., Abe, Y., Mikurita, H., Yuzawa, K. and Hiraga, K.
1977. Pathological examination of rats fed with linear alkylbenzene
sulfonate for their lifespan. Ann. Rep. Tokyo Metrop. Res. Lab. Public
Health. 28:85-108 (in Japanese); cited in: IPCS (1996); Environmental
Health Criteria 169: Linear Alkylbenzene Sulfonates (LAS) and Related
Compounds. WHO, Geneva, Switzerland.
3) Yoneyama, M., Masubuchi, M., Oishi, S., Takahashi, O., Ikawa, M.,
Yoshida, S., Oishi, H., Mikuriya, H., Yuzawa, K. and Hiraga, K. 1977.
Subacute toxicity of linear alkylbenzene sulfonate. Ann. Rep. Tokyo
Metrop. Res. Lab. Public Health. 28:73-84 (in Japanese); cited in: IPCS
(1996); Environmental Health Criteria 169: Linear Alkylbenzene Sulfonates
(LAS) and Related Compounds. WHO, Geneva, Switzerland.
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document.
5.8 TOXICITY TO REPRODUCTION
(a)
Type: Fertility [ ]; One-generation study [ ]; Two-generation study [ ];
Other [X] : 3-generation reproduction study
Species/strain: Rat: Charles River
Sex: Female [ ]; Male [ ]; Male/Female [X]; No data [ ]
Administration: oral feed
Exposure period: 2 years
Frequency of treatment:continuous in feed
Premating
exposure period: male: 84 days, female: 84 days
Duration of the test: 3 generations
Doses: 0.02, 0.1, 0.5% (14, 70, 350 mg/kg bw d)
Control group: Yes [X]; No [ ]; No data [ ];
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