LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
dosing. Signs of reaction to treatment included pilo-erection, hunched
posture, abnormal gait (waddling), lethargy, decreased respiratory rate,
ptosis, pallor of the extremities, and diarrhea. All surviving animals
appeared to recover completely by day 4. Autopsy of rats that died revealed
isolated cases of pallor of the kidneys or spleen. Terminal necropsy findings
for survivors were normal. Note that all doses are corrected for 47% activity.
The original doses were 3200, 5000, and 8000 mg/kg.
Reference: Kynoch, S.R. 1986a. Acute oral toxicity to rats: P-500 N-Na. Huntingdon
Research Cener Report. No. 86546D/PEQ 7/AC.
Reliability: 1 Valid without restriction
(f)
Type: LD0 [ ]; LD100 [ ]; LD 50 [X]; LDL0 [ ]; Other [ ]
Species/strain: Sprague-Dawley strain albino male and female rats
Value: 1320 mg/kg (lower limit: 1220 mg/kg; upper limit: 1430 mg/kg)
Method: Acute Oral Minimal Lethal Dose Test
The test substance was applied as a 20% aqueous solution by stomach tube to
Sprague-Dawley strain albino male and female rats. After the approximate
LD50 was determined, groups of male and female rats were fed in increasing
doses at increments of 0.1 fractional log intervals at three levels (1000, 1260
and 1580 mg/kg) designed to blanket the toxicity range thereby supplying
data for calculation of the LD50 which was performed according to the
method of E.J. de Beer. Observations of toxic signs were recorded and the
viscera of the test animals were examined macroscopically.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-225); C9 1%; C10 7%, C11
25%, C12 48%, C13 19%, C14 1%; average alkyl chain length = C11.9.
Remarks: The compound was classified as mildly toxic by oral ingestion in male and
female rats. All rats at 1000 mg/kg and 4 of 5 rats at 1260 mg/kg survived.
Survival time was one to two days for rats that died at 1580 mg/kg. The
toxic signs included reduced appetite and activity (one to two days in
survivors), diarrhoea, increasing weakness, collapse, and death. The autopsy
revealed hemorrhagic lungs, liver discoloration, and acute gastrointestinal
inflammation. Surviving animals were sacrificed seven days after dosing. In
these animals the vircera appeared normal by macroscopic examination.
Reference: Monsanto Company. 1971. Linear alkylbenzene sodium sulfonate –
Alkylate 225 Lot CC 6450 – Acute toxicity screen. Project No. Y-71-119.
Unpublished report.
Reliability: 2 Valid with restrictions
(g)
Type: LD0 [ ]; LD100 [ ]; LD 50 [X]; LDL0 [ ]; Other [ ]
Species/strain: Sprague-Dawley strain albino male and female rats
Value: 1430 mg/kg (lower limit: 1300 mg/kg; upper limit: 1570 mg/kg)
Method: Acute Oral Minimal Lethal Dose Test
The test substance was applied as a 10% aqueous solution by stomach tube to
Sprague-Dawley strain albino male and female rats. After the approximate
LD50 was determined, groups of male and female rats were fed in increasing
doses at increments of 0.1 fractional log intervals at four levels (1000, 1260,
1580 and 2000 mg/kg) designed to blanket the toxicity range thereby
supplying data for calculation of the LD50 which was performed according to
the method of E.J. de Beer. Observations of toxic signs were recorded and
the viscera of the test animals were examined macroscopically.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-215); C9 1%, C10 16%, C11
43%, C12 40%, C13 1%, C14