LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) Recovery in humans was similar to that reported previously, supporting milder irritation response and faster healing in humans than in rabbits. Reference: Freeberg, F.E., Griffith, J.F., Bruce, R.D., and Bay, P.H.S. 1984. Correlation of animal test methods with human experience for household products. J. Toxicol.- Cut. & Ocular Toxicol. 1:53-64. Freeberg, F.E., Hooker, D.T., and Griffith, J.F. 1986. Correlation of animal eye test data with human experience for household products: an update. J. Toxicol.- Cut. & Ocular Toxicol. 5:115-123. Cormier, E.M., Hunter, J. E., Billhimer, W., May, J., and Farage, M.A. 1995. Use of clinical and consumer eye irritation data to evaluate the low-volume eye test. J. Toxicol.- Cut. & Ocular Toxicol. 14:197-205. Reliability: 2 Valid with restrictions (e) Type: Characterization of aerosols generated from a consumer spray product Methods: The study was designed to evaluate size distribution of aerosols suspended in air after normal use of consumer spray products. Size distribution of aerosols generated from six different consumer trigger spray product nozzles was measured using a laser diffraction particle sizer (Mastersizer Model X, Malvern Instruments Ltd). A 300 mm receiving lens was used, which covers a particle size range of 1.2-600 microns. The exit of the trigger sprayer was positioned at 20 mm from the lens to the center of the device to avoid vignetting, and 120 mm from the laser beam axis to the tip of the trigger sprayer to avoid its interference with the laser beam. Measurements were repeated 5 times for each sprayer. Results: The overall mean (n=30) particle size is 0.11% particles under 10 microns, with a standard deviation of 0.21. The very highest observation was 0.80%. Under normal use conditions, the peak breathing zone concentration under 10 microns ranged from 0.13 to 0.72 mg/m 3 . Remarks: This testing only captured the spray particles that are under 600 microns, so the actual percentage of total volume sprayed is less than 0.1%. Reference: Battelle. 1999. Measurement and Characterization of Aerosols Generated from a Consumer Spray Product – Pilot Study. Prepared for The Soap and Detergent Association. Battelle Study No. N003043A, January 18, 1999. Reliability: 1 Valid without restriction (f) Type: Modeling of dose observed from inhalation of aerosols Methods: The worst case air concentration of LAS resulting from use in surface cleaning spray products was modeled using methods recommended by the HERA Guidance Document (06/2001). In this modeling, HERA reports the results of experimental measurements of the concentration of aerosol particles from a 2001 Procter & Gamble study. The following algorithm was used to model the absorbed dose: Expsys = F1 · C’ · Qinh · t · n · F7 · F8/bw (mg/kg bw/day) Where: Expsys = dose absorbed via inhalation F1 = weight fraction of substance in product = 6% (worst case assumption) C’ = product concentration = 0.35 mg/m 3 Qinh = ventilation rate of user = 0.8 m 3 /hr t = duration of exposure = 0.17 hr (10 minutes) n = product use frequency, in number of events per day = 1 F7 = weight fraction respirable = 100% F8 = weight fraction absorbed or bioavailable = 75% UNEP PUBLICATIONS 308
OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) bw = body weight = 60 kg Results: The modeling resulted in an Expsys (inhalation of aerosols) = 0.04 µg/kg bw/day. Measured aerosol particles under 6.4 microns in size were generated upon spraying with typical surface cleaning spray products, resulting in a product concentration of 0.35 mg/m 3 . Reference: HERA. 2002. HERA-LAS Human and Environmental Risk Assessment: Linear Alkylbenzene Sulphonates, LAS. CAS No. 68411-30-3, Draft, July 2002. http://www.heraproject.com/riskassessment.cfm Reliability: 4 This score was assigned because the original Procter & Gamble study and the HERA model inputs were not available for review. However, the study and all assumptions were evaluated by HERA. UNEP PUBLICATIONS 309
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LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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