LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals
LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals
LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals
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OECD SIDS <strong>LINEAR</strong> <strong>ALKYLBENZENE</strong> <strong>SULFONATE</strong> (<strong>LAS</strong>)<br />
Recovery in humans was similar to that reported previously, supporting<br />
milder irritation response and faster healing in humans than in rabbits.<br />
Reference: Freeberg, F.E., Griffith, J.F., Bruce, R.D., and Bay, P.H.S. 1984. Correlation<br />
of animal test methods with human experience for household products. J.<br />
Toxicol.- Cut. & Ocular Toxicol. 1:53-64.<br />
Freeberg, F.E., Hooker, D.T., and Griffith, J.F. 1986. Correlation of animal<br />
eye test data with human experience for household products: an update. J.<br />
Toxicol.- Cut. & Ocular Toxicol. 5:115-123.<br />
Cormier, E.M., Hunter, J. E., Billhimer, W., May, J., and Farage, M.A. 1995.<br />
Use of clinical and consumer eye irritation data to evaluate the low-volume<br />
eye test. J. Toxicol.- Cut. & Ocular Toxicol. 14:197-205.<br />
Reliability: 2 Valid with restrictions<br />
(e)<br />
Type: Characterization of aerosols generated from a consumer spray product<br />
Methods: The study was designed to evaluate size distribution of aerosols suspended in<br />
air after normal use of consumer spray products. Size distribution of<br />
aerosols generated from six different consumer trigger spray product nozzles<br />
was measured using a laser diffraction particle sizer (Mastersizer Model X,<br />
Malvern Instruments Ltd). A 300 mm receiving lens was used, which covers<br />
a particle size range of 1.2-600 microns. The exit of the trigger sprayer was<br />
positioned at 20 mm from the lens to the center of the device to avoid<br />
vignetting, and 120 mm from the laser beam axis to the tip of the trigger<br />
sprayer to avoid its interference with the laser beam. Measurements were<br />
repeated 5 times for each sprayer.<br />
Results: The overall mean (n=30) particle size is 0.11% particles under 10 microns,<br />
with a standard deviation of 0.21. The very highest observation was 0.80%.<br />
Under normal use conditions, the peak breathing zone concentration under<br />
10 microns ranged from 0.13 to 0.72 mg/m 3 .<br />
Remarks: This testing only captured the spray particles that are under 600 microns, so<br />
the actual percentage of total volume sprayed is less than 0.1%.<br />
Reference: Battelle. 1999. Measurement and Characterization of Aerosols Generated<br />
from a Consumer Spray Product – Pilot Study. Prepared for The Soap and<br />
Detergent Association. Battelle Study No. N003043A, January 18, 1999.<br />
Reliability: 1 Valid without restriction<br />
(f)<br />
Type: Modeling of dose observed from inhalation of aerosols<br />
Methods: The worst case air concentration of <strong>LAS</strong> resulting from use in surface<br />
cleaning spray products was modeled using methods recommended by the<br />
HERA Guidance Document (06/2001). In this modeling, HERA reports the<br />
results of experimental measurements of the concentration of aerosol<br />
particles from a 2001 Procter & Gamble study. The following algorithm was<br />
used to model the absorbed dose:<br />
Expsys = F1 · C’ · Qinh · t · n · F7 · F8/bw (mg/kg bw/day)<br />
Where:<br />
Expsys = dose absorbed via inhalation<br />
F1 = weight fraction of substance in product = 6% (worst case assumption)<br />
C’ = product concentration = 0.35 mg/m 3<br />
Qinh = ventilation rate of user = 0.8 m 3 /hr<br />
t = duration of exposure = 0.17 hr (10 minutes)<br />
n = product use frequency, in number of events per day = 1<br />
F7 = weight fraction respirable = 100%<br />
F8 = weight fraction absorbed or bioavailable = 75%<br />
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