LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) Administration: i.m. [ ]; i.p. [ ]; i.v. [X]; infusion [ ]; s.c. [ ]; other [ ] Value: Females = 298 mg/kg; males = 207 mg/kg bw Method: Mice were given intravenous injections of LAS. GLP: Yes [ ] No [X] ? [ ] Test substance: C10-13 LAS, sodium salt (CAS #68411-30-3)
OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) was observed in all three animals. The reaction in all three animals gradually ameliorated from Days 5, 10 and 11, respectively, and had all resolved completely in one animal by Day 12. Reference: Liggett, M.P. and Parcell, B.I. 1986a. Irritant effects on rabbit skin of P-500 N-Na. Huntingdon Research Center. Report No. 86400D/PEQ 9/SE. Reliability: 1 Valid without restriction (b) Species/strain: New Zealand albino rabbits Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ]; Irritating [X]; Moderate irritating [ ]; Slightly irritating [ ]; Not irritating [ ] Method: OECD Guideline 404. A single dose of 0.5 g was applied to the clipped intact skin of six rabbits and secured with a gauze pad covered by an impermeable covering. The patch was removed after a 4 hour exposure and the site washed with water. Animals were examined for signs of erythema and oedema and the responses scored at 60 minutes, 24, 48 and 72 hr, and daily as needed up to 7 days. Skin irritation was scored using the standard rating system and averaged. GLP: Yes [ ] No [X] ? [ ] Test substance: LAS activity 50%; average alkyl chain length = C11.6 Remarks: Average score after 72 hours were 2.4 and 2.83 for erythema and oedema, respectively. Reference: Biolab SGS. 1989a. Primary skin irritation. Report No. T00428/4. Reliability: 2 Valid with restrictions (c) Species/strain: rabbit Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ]; Irritating [X]; Moderate irritating [ ]; Slightly irritating [ ]; Not irritating [ ] Classification: Highly corrosive (causes severe burns) [ ]; Corrosive (causes burns) [ ]; Irritating [X]; Not irritating [ ] Method: OECD Guide-line 404 "Acute Dermal Irritation/Corrosion" 1984 GLP: Yes [X] No [ ] ? [ ] Test substance: C10 LAS (CAS #1322-98-1) and C12 LAS (CAS #25155-30-0). Remarks: Reference reports the results of many experiments conducted on LAS and other surfactants. Reference: Kaestner, W. 1997. Local tolerance (animal tests): mucous membranes and skin. In: Anionic Surfactants: Biochemistry, Toxicology, Dermatology. 2 nd Edition. Reliability: 4 Not assignable (d) Species/strain: rabbit Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ]; Irritating [X]; Moderate irritating [ ]; Slightly irritating [ ]; Not irritating [ ] Classification: Highly corrosive (causes severe burns) [ ]; Corrosive (causes burns) [ ]; Irritating [X]; Not irritating [ ] Method: OECD Guide-line 404 "Acute Dermal Irritation/Corrosion" 1981. Three male and female rabbits received 0.5 ml of 50% active material to the shaved intact skin. GLP: Yes [ ] No [X] ? [ ] Test substance: Marlon A 350 (CAS # 68411-30-3) C10-13 LAS, average alkyl chain length = C11.6; activity: 50%. UNEP PUBLICATIONS 261
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