LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

More documents

Recommendations

Info

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) Results: Diarrhea was observed in the 500 mg/kg group and soft stools were observed in the other 2 groups. Body weight gain was suppressed in all the male groups and in the female 500 mg/kg group. Haematological examinations revealed no abnormalities. Serum-biochemical examinations revealed several differences among the mid and high dose group compared to the control group. The weight of the spleen and the heart significantly decreased in the male high dose group. In the female high dose group, the weight of the liver increased while the weight of the heart and thymus decreased. Histological findings of the liver revealed no abnormalities. GLP: Yes [ ] No [X] ? [ ] Remarks: Information as cited in IPCS document. 12 animals per dose group. Test substance: C10-13 LAS, sodium salt (CAS #68411-30-3)
OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) Reliability: 4 This study is assigned a reliability score of 4 because the original report was not available for review. However, the study was evaluated by IPCS prior to inclusion in their criteria document. (e) Species/strain: Rat (Wistar) Sex: Female [ ]; Male [X]; Male/Female [ ]; No data [ ] Administration: oral feed Exposure period: 2, 4, 12 weeks Frequency of treatment: Daily in feed Dose: 1.5% (750 mg/kg bw d) Control group: Yes [X]; No [ ]; No data [ ]; Concurrent no treatment [ ]; Concurrent vehicle [ ]; Historical [ ] LOAEL: 1.5% (750 mg/kg bw d) Results: LAS suppressed body weight gain, and the relative liver weight was increased from 2 weeks of LAS administration. Serum biochemical examinations revealed significant increases in ALP and GTP at each observation period and significant decreases in cholesterol and protein in 4 weeks. Enzymatic examinations of the liver revealed decreases in G6Pase and G6PDH and an increase in isocitrate dehydrogenase (IDH) at each observation period. Enzymatic examinations of the renal cortex revealed decreases in G6Pase and 5'-nucleotidase at each observation period, an increase in LDH at 12 weeks, and an increase in IDH at 2 and 4 weeks. Enzymatic examinations in the renal medulla revealed a decrease in NA,K- ATPase, an increase in LDH at 12 weeks, a decrease in IDH at 2 weeks, and an increase in IDH at 12 weeks. GLP: Yes [ ] No [X] ? [ ] Test substance: LAS (unspecified) Remarks: Information as cited in IPCS document. Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts. Year 2000 CD-ROM edition. 2) Ikawa, M., Yoneyama, M., Nakao, T. and Hiraga, K. 1978. Uptake of organic acid and organic base by renal cortical slices of rats treated with LAS and ABS. Ann. Rep. Tokyo Metr. Res. Lab. P.H. 29:51-54 (in Japanese); cited in: IPCS (1996); Environmental Health Criteria 169: Linear Alkylbenzene Sulfonates (LAS) and Related Compounds. WHO, Geneva, Switzerland. Reliability: 4 This study is assigned a reliability score of 4 because the original report was not available for review. However, the study was evaluated by IPCS prior to inclusion in their criteria document. (f) Species/strain: Rat (Wistar) Sex: Female [ ]; Male [ ]; Male/Female [X]; No data [ ] Administration: oral feed Exposure period: 6 months Frequency of treatment: Daily in feed Dose: 0.07, 0.2, 0.6, 1.8% (40, 115, 340, 1030 mg/kg bw d) Control group: Yes [X]; No [ ]; No data [ ]; Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ] NOAEL: = 40 mg/kg bw d LOEL: = 115 mg/kg bw d Results: The 1.8% group showed diarrhoea, markedly suppressed growth, increased weight of the cecum, and remarkable degeneration of the renal tubes. The 0.6% group showed slightly suppressed growth, increased weight of the cecum, increased activity of serum alkaline phosphatase (ALP), a decrease in UNEP PUBLICATIONS 273
Page 1 and 2:
OECD SIDS LINEAR ALKYLBENZENE SULFO
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
Page 39 and 40:
Page 41 and 42:
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78:
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Page 95 and 96:
Page 97 and 98:
Page 99 and 100:
Page 101 and 102:
Page 103 and 104:
Page 105 and 106:
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222: OECD SIDS LINEAR ALKYLBENZENE SULFO
Page 271: OECD SIDS LINEAR ALKYLBENZENE SULFO
Page 323 and 324:
Page 325 and 326:
Page 327 and 328:
Page 329 and 330:
Page 331 and 332:
Page 333 and 334:
Page 335 and 336:
Page 337 and 338:
Page 339 and 340:
Page 341 and 342:
Page 343 and 344:
Page 345 and 346:
Page 347 and 348:
Page 349 and 350:
Page 351 and 352:
Page 353 and 354:
Page 355 and 356:
Page 357:
show all

LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?