LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Metabolic activation: With [ ]; Without [ ]; With and Without [X]; No data [ ]
Results:
Cytotoxicity conc: With metabolic activation: > 500 µg/plate
Without metabolic activation: > 500 µg/plate
Genotoxic effects: + ? -
With metabolic activation: [ ] [ ] [X]
Without metabolic activation: [ ] [ ] [X]
Method: Ames test
GLP: Yes [ ] No [X] ? [ ]
Test substance: C10-14 LAS, sodium salts (CAS #69669-44-9); average alkyl chain length
(based on LAS SIDS Consortium Survey, 2000) = C11.7; activity: 20.5%
Remarks: Information as cited in IPCS documents. Not mutagenic
Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs.,
sodium salts. Year 2000 CD-ROM edition.
2) Sunakawa, T., Inoue, K. and Okamoto, K. 1981. Studies on the
mutagenicity of surfactants, mutagenicity of surfactants following activation
with various liver homogenates (S-9) and mutagenicity in the presence of
norharman. Hyg. Chem. 27:204-211. (In Japanese); Cited in IPCS. 1996.
Environmental Health Criteria 169: Linear Alkylbenzene Sulfonates and
Related Compounds. World Health Organization, Geneva, Switzerland.
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document.
(d)
Type: Bacillus subtilis recombination assay
System of testing: H17 (rec+) and M45 (rec-)
Concentration: Up to 50 µg/plate
Metabolic activation: With [ ]; Without [ ]; With and Without [X]; No data [ ]
Results:
Cytotoxicity conc: With metabolic activation: > 50 µg/plate
Without metabolic activation: > 50 µg/plate
Genotoxic effects: + ? -
With metabolic activation: [ ] [ ] [X]
Without metabolic activation: [ ] [ ] [X]
Method: Bacillus recombination assay
GLP: Yes [ ] No [X] ? [ ]
Test substance: C10-14 LAS, sodium salts (CAS #69669-44-9); average alkyl chain length
(based on LAS SIDS Consortium Survey, 2000) = C11.7; activity: 99.5%
Remarks: Information as cited in IPCS document.
Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs.,
sodium salts. Year 2000 CD-ROM edition.
2) Inoue, IK. and Sunakawa, T. 1979. Mutagenicity tests of surfactants. Jpn
Fragrance J. 38:67-75 (in Japanese); cited in: IPCS (1996); Environmental
Health Criteria 169: for Linear Alkylbenzene Sulfonates (LAS) and Related
Compounds. WHO, Geneva, Switzerland.
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document.
(e)
Type: Escherichia coli reverse mutation assay.
System of testing: WP23 uvr A
Concentration: Not specified
Metabolic activation: With [ ]; Without [ ]; With and Without [X]; No data [ ]
Results:
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