LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
2) Tiba, S. 1972. Studies on the acute and chronic toxicity of linear
alkylbenzene sulfonate. J. Food Hyg. Soc. Jpn. 16:66-71 (in Japanese); cited
in: IPCS (1996); Environmental Health Criteria 169: Linear Alkylbenzene
Sulfonates (LAS) and Related Compounds. WHO, Geneva, Switzerland.
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document
(c)
Species/strain: Rat/Wistar
Sex: Female [ ]; Male [ ]; Male/Female [X]; No data [ ]
Administration: drinking water
Exposure period: up to 26 months
Frequency of treatment: Daily
Doses: 0.1% (140 mg/kg bw d)
Control group: Yes [X]; No [ ]; No data [ ];
Concurrent no treatment [ ]; Concurrent vehicle [ ]; Historical [ ]
Results: The administration of LAS had no effect on the intake of water, mortality,
body weight gain, or general condition. In pathological examination,
looseness, atrophy, and fatty change of the hepatic cells in the liver were
found in the experimental group at 6 months. The experimental group
showed significant increases in GOT, GTP and bilirubin at 6 months and
thereafter. In haematological examinations no effects due to LAS were
observed.
Method: A group of 62 male and 62 female rats were given drinking water treated
with LAS and a control group of 37 male and 37 female rats were given pure
water. Five to 12 of the rats in the experimental group and 3 to 12 rats in the
control group at 3, 6, 12, and 18 months, respectively, and all surviving rats
between 24 and 26 months, were sacrificed for pathological, biochemical,
and haematological examinations.
GLP: Yes [ ] No [X] ? [ ]
Test substance: LAS; mean molecular weight 348; average alkyl chain length = C12.0;
activity: 38.74%
Remarks: Information as cited in the IPCS document.
Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs.,
sodium salts. Year 2000 CD-ROM edition.
2) Endo, T., Furuido, Y., Namie, K., Yamamoto, N., Hasunuma, H. and
Ueda, K. 1980. Studies of the chronic toxicity and teratogenicity of
synthetic surfactants. Ann. Rep. Tokyo Metrop. Res. Inst. Environ. Prot.
236-246 (in Japanese); cited in: IPCS (1996); Environmental Health Criteria
169: Linear Alkylbenzene Sulfonates (LAS) and Related Compounds.
WHO, Geneva, Switzerland.
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document.
(d)
Species/strain: Rat/Wistar
Sex: Female [ ]; Male [ ]; Male/Female [X]; No data [ ]
Administration: oral feed
Exposure period: 1, 3, 6, 24, or more months
Frequency of treatment: Daily
Doses: 0.04, 0.16, 0.6% (20, 80, 300 mg/kg bw d)
Control group: Yes [X]; No [ ]; No data [ ];
Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ]
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