LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
5. TOXICITY
5.1 ACUTE TOXICITY
5.1.1 ACUTE ORAL TOXICITY
(a) (Rat)
Type: LD0 [ ]; LD100 [ ]; LD 50 [X]; LDL0 [ ]; Other [ ]
Species/strain: rat
Value: 1080 mg/kg bw
Method: OECD Guide-line 401 "Acute Oral Toxicity" 1981. Five male and five
female rats were given LAS doses of 1075, 1220, 1360, 1710 or a control by
gavage. Body weight and other signs were measured on days 7 and 14.
Temperature was maintained at 20 + /-1 o C with a 12 hr light-dark cycle.
Animals were observed for 14 days after dosing.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Marlon A 386 (CAS #68411-30-3) C10-13 LAS, average alkyl chain length =
C11.6; Activity: 86%
Remarks: Symptoms beginning about 30 minutes past application included diarrhea,
squatting attitude, breathing difficulties, nose bleeding, ataxia, and lethargy.
These symptoms had disappeared in surviving animals by 120 hours.
Virtually all animals died in doses of 1220 mg/kg and above. Note that all
doses are corrected for 86% activity. The original doses were 1250, 1415,
1580 and 1990 mg/kg.
Reference: Murmann, P. 1984a. Akute orale Toxizitat von Marlon A 386 fur Ratten.
Huels Report No. 0191.
Reliability: 2 Valid with restrictions
(b)
Type: LD0 [ ]; LD100 [ ]; LD 50 [X]; LDL0 [ ]; Other [ ]
Species/strain: rat
Value: 1630 mg/kg bw
Method: OECD Guide-line 401 "Acute Oral Toxicity" 1981. Five male and five
female rats were given LAS doses of 1260, 1580, 1785, and 1990 or a control
by gavage. Body weight and other signs were measured on days 7 and 14.
Temperature was maintained at 20 + /-1 o C with a 12 hr light-dark cycle.
Animals were observed for 14 days after dosing.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Marlon A 350 (CAS #68411-30-3) C10-13 LAS, average alkyl chain length =
C11.6; Activity: 50%
Remarks: Symptoms beginning about 1-4 hours past application included diarrhea,
squatting attitude, breathing difficulties, nose bleeding, ataxia, and lethargy.
The symptoms in the lower doses disappeared with 24 to 48 hours.
Symptoms disappeared in the 1785 mg/kg dose and higher within 8 days.
Virtually all animals died in doses of 1785 mg/kg and above. Note that all
doses are corrected for 50% activity. The original doses were 2510, 3160,
3570 and 3980 mg/kg.
Reference: Murmann, P. 1984c. Akute orale Toxizitat von Marlon A 350 fur Ratten.
Huels Report No. 209.
Reliability: 2 Valid with restrictions
(c)
Type: LD0 [ ]; LD100 [ ]; LD 50 [X]; LDL0 [ ]; Other [ ]
Species/strain: rat
Value: 1410 mg/kg bw
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