LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Remarks: Mean irritation index: 5.1 out of 8. Individual scores: edema: 2.28,
erythema: 3.0
Reference: Murmann, P. 1983a. Prufung der akuten Hautreizwirkung von Marlon A
350. Huels Report No. 0171.
Reliability: 2 Valid with restrictions
(e)
Species/strain: New Zealand albino rabbits
Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ];
Irritating [ ]; Moderately irritating [X]; Slightly irritating [ ];
Not irritating [ ]
Method: OECD Guideline 404. A single dose of 0.5 g was applied to the clipped
intact skin of six rabbits and secured with a gauze pad covered by an
impermeable covering. The patch is removed after a 4 hour exposure and the
site washed with water. A second site with the skin abraded received the
same treatment. Animals are examined for signs of erythema and oedema
and the responses scored at 60 minutes, 24, 48 and 72 hr, and daily as needed
up to 7 days. Skin irritation is scored using the standard rating system and
averaged.
GLP: Yes [ ] No [X] ? [ ]
Test substance: LAS (made from Sirene LAB); activity 5%; average alkyl chain length =
C11.6
Remarks: Average scores after 72 hours were 1.67 and 2.17 for erythema and oedema,
respectively. The primary irritation index was calculated to be 3.82, which
classifies 5% LAS as a moderate skin irritant. No differences were observed
between intact and abraded skin.
Reference: Biolab SGS. 1989b. Primary skin irritation. Report No. T343.
Reliability: 2 Valid with restrictions
(f)
Species/strain: New Zealand albino rabbits
Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ];
Irritating [ ]; Moderate irritating [ ]; Slightly irritating [ ];
Not irritating [X]
Method: OECD Guideline 404. A single dose of 0.5 g was applied to the clipped
intact skin of six rabbits and secured with a gauze pad covered by an
impermeable covering. The patch is removed after a 4 hour exposure and the
site washed with water. A second site with the skin abraded received the
same treatment. Animals are examined for signs of erythema and oedema
and the responses scored at 60 minutes, 24, 48 and 72 hr, and daily as needed
up to 7 days. Skin irritation is scored using the standard rating system and
averaged.
GLP: Yes [ ] No [X] ? [ ]
Test substance: LAS (made from Sirene LAB); activity 2.5%; average alkyl chain length =
C11.6
Remarks: No signs of irritation were observed during the study.
Reference: Biolab SGS. 1989c. Primary skin irritation. Report No. T00430/2.
Reliability: 2 Valid with restrictions
(g)
Species/strain: New Zealand albino rabbits
Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ];
Irritating [ ]; Moderate irritating [ ]; Slightly irritating [ ];
Not irritating [X]
Method: OECD Guideline 404. A single dose of 0.5 g was applied to the clipped
intact skin of six rabbits and secured with a gauze pad covered by an
UNEP PUBLICATIONS 262