LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document.
(i)
Species/strain: Mouse/ICR.
Sex: Female [X]; Male [ ]; Male/Female [ ]; No data [ ]
Administration: gavage
Duration of the test: see text.
Exposure period: day 6 through day 15 of pregnancy.
Frequency of treatment:daily.
Doses: 10, 100, 300 mg/kg bw d
Control group: Yes [X]; No [ ]; No data [ ];
Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ]
LOAEL Maternal
Toxicity: 10 mg/kg bw d
NOAEL teratogenicity: 300 mg/kg bw d
Results: The dams showed inhibition of body weight gains in all groups, especially in
the high dose group. In this group, two dams died, and there was one case of
premature delivery and death of all fetuses. There were findings such as
decreased body weight and delayed ossification among the living fetuses, but
there was no increase in malformations.
Method: LAS was administered by gavage to 25 to 33 mice per dose on days 6
through 15 of gestation.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Japan LAS; average alkyl chain length (based on LAS SIDS Consortium
Survey, 2002) = C11.7-12.3; activity: 48.6%
Remarks: Information as cited in the IUCLID Data Sheet and the IPCS document.
Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs.,
sodium salts. Year 2000 CD-ROM edition.
2) Shiobara, S. and Imahori, A. 1976. Effects of linear alkylbenzene
sulfonate orally administered to pregnant mice and their fetuses. J. Food
Hyg. Soc. Jpn. 17:295-301 (in Japanese); cited in: IPCS (1996);
Environmental Health Criteria 169: Linear Alkylbenzene Sulfonates (LAS)
and Related Compounds. WHO, Geneva, Switzerland.
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document.
(j)
Species/strain: Rat: SD-JCL
Sex: Female [X]; Male [ ]; Male/Female [ ]; No data [ ]
Administration: oral feed
Exposure period: from day 0 to 20 of gestation
Frequency of treatment: Daily
Doses: 0.1%, 1.0% (80, 780 mg/kg bw d)
Control group: Yes [X]; No [ ]; No data [ ];
Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ]
NOAEL Maternal: 780 mg/kg bw d
NOAEL teratogenicity: 780 mg/kg bw d
Results: The LAS intake was about 780 mg/kg with the 1% diet, but there were no
abnormalities in the body weight gains of the dams, or in the occurrence and
maintenance of pregnancy. The values of the litter parameters did not differ
from those of the controls and there was no evidence of teratogenicity. The
numbers of offspring were rather low in the 1% group, and the weaning rate
of 78.3% was lower than the 100% rate observed in the controls. However,
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