LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
there were no abnormalities in body weight gain, organ weights or functions
in the offspring.
Method: LAS was fed in the diet to 16 pregnant female rats/dose from day 0 to 20 of
gestation.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Japan LAS; average alkyl chain length (based on LAS SIDS Consortium
Survey, 2002) = C11.7-12.3.
Remarks: Information as cited in IUCLID Data Sheet and IPCS document.
Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs.,
sodium salts. Year 2000 CD-ROM edition.
2) Tiba, S., Shiobara, S., Imahori, A. and Kitagawa, T. 1976. Effects of
linear alkylbenzene sulfonate on dam, fetus and newborn rat. J. Food Hyg.
Soc. Jpn. 17:66-71. (In Japanese); cited in IPCS. 1996. Environmental
Health Criteria 169: Linear Alkylbenzene Sulfonates and Related
Compounds. World Health Organization, Geneva, Switzerland. Original
article in Japanese.
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document.
(k)
Species/strain: Weanling Charles River CD Sprague-Dawley albino rats and
New Zealand rabbits
Sex: Female [ ]; Male [ ]; Male/Female [X]; No data [ ]
Administration: oral in feed
Duration of the test: two generation (rats); one generation (rabbits)
Exposure period: Rat: continuously or during organogenesis period of six pregnancies
Rabbit: day 2-16 of gestation during a single pregnancy
Frequency of treatment:continuous
Doses: Rat: 0.1, 0.5 or 1.0% TAE3S/LAS (equivalent to 50, 250 or 500 mg/kg/day in
female rats corresponding to LAS doses of 22.5, 112.5 and 225 mg/kg bw d.)
Rabbit: 50, 100, or 300 mg/kg TAE3S/LAS, corresponding to LAS doses of
22.5, 45, and 135 mg/kg bw d
Control group: Yes [X]; No [ ]; No data [ ];
Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ]
NOAEL Maternal: 225 mg/kg bw d LAS (rat)
135 mg/kg bw d LAS (rabbit)
NOAEL teratogenicity: 225 mg/kg bw d LAS (rat)
135 mg/kg bw d LAS (rabbit)
Results: Maternal toxicity: No treatment related adverse effects were observed in the
maternal generation of either rats or rabbits. Fetal toxicity: No treatmentrelated
adverse effects were observed on conception, fetal viability or postnatal
survival in either generation of rats. Some statistically significant
differences were observed in live-born and surviving pup numbers, but there
were no consistent trend or patterns. Combined with the high lactation index
in all groups, indicating a very low mortality among the suckling rats, these
differences were considered due to causes not related to treatment with the
test material. There were no statistical differences among the groups of rat
fetuses taken by Caesarian section and examined for birth defects. Some
minor soft-tissue and skeletal anomalies were observed in rat fetuses from
both generations. Of the 1210 rat fetuses, the overall incidence of abnormal
young was 9.0% and did not vary significantly between treatment groups or
the controls. Similarly, no treatment-related adverse effects were seen in
rabbits treated with the surfactant mixture. Of the 855 rabbit fetuses, 5.7%
were abnormal, but the incidence of defective fetuses in the test groups were
not significantly different from those in controls. Therefore, no test related
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