LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Remarks: All of the effects observed are related to energy metabolism, so given the
lack of morphological and structural changes, the reduced food intake and
body weight gain may have compromised energy dynamics and affected the
enzyme levels. The reliability and use of this study for risk assessment
purposes is limited and the 50 mg/kg/day level should be considered a LOEL
rather than a LOAEL.
Test Substance: Commercial LAS synthetic detergent solution
Reference: 1) Gupta, B.N., Mathur, A.K., Agarwal, C., and Singh, A. 1986. Effect of
synthetic detergent on certain enzymes in liver and kidney in male rats.
Arogya-J. Health Sci. 12:50-54.
2) Mathur, A.K., Gupta, B.N., Singh, A., and Shanker, R. 1986.
Toxicological evaluation of a synthetic detergent after repeated oral ingestion
in rats. Biol. Mem. 12:187-191.
Reliability: 2 Valid with restrictions
(h)
Species/strain: Rat (Wistar)
Sex: Female [ ]; Male [ ]; Male/Female [X]; No data [ ]
Administration: drinking water
Exposure period: 9 months
Frequency of treatment: Daily in drinking water.
Dose: 0.07, 0.2%, 0.6% (85, 145, 430 mg/kg bw d; average of male and female)
Control group: Yes [X]; No [ ]; No data [ ];
Concurrent no treatment [ ]; Concurrent vehicle [ ]; Historical [ ]
NOAEL: 0.07% (85 mg/kg bw d)
LOAEL: 0.2% (145 mg/kg bw d)
Results: Body weight gain was suppressed in the male 0.6% group. Hematological
examination revealed no significant change in any of the experimental
groups, but a dose-related decrease in cholesterol level was seen in males.
Significant decreases in the activities of glutamate-oxalate transaminase and
lactate dehydrogenase were seen in males at 0.2% and a dose-related increase
in the activity of glutamate-oxalate transaminase in females. A significant
decrease in renal Na,K-ATPase was seen in the group given 0.2%. No organ
weight changes were observed. The intake of LAS was 50 mg/kg bw d in the
male 0.07% group and 120 mg/kg bw d in the female group. The values for
the 0.2% group were 120 and 170 mg/kg bw d for males and females,
respectively.
Method: Groups of 8-9 male and 8-9 female rats were given LAS for 9 months.
GLP: Yes [ ] No [X] ? [ ]
Remarks: Information as cited in IPCS document. This is a key study for repeated dose
toxicity because it represents the highest NOAEL below the lowest LOAEL
(see SIAR Table 6).
Test substance: C10-14 LAS (CAS #69669-44-9); average alkyl chain length (based on LAS
SIDS Consortium Survey, 2000) = C11.7
Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs.,
sodium salts. Year 2000 CD-ROM edition.
2) Yoneyama, M., Mabuchi, Y., Ikawa, M., Kobayashi, H. and Ichikawa, H.
1976. Subacute toxicity of linear alkylbenzene sulfonate. Ann. Rep. Tokyo
Metr. Res. Lab. Public Health 27:105-112 (in Japanese); cited in: IPCS
(1996); Environmental Heath Criteria 169: Linear Alkylbenzene Sulfonates
(LAS) and Related Compounds. WHO Geneva, Switzerland.
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document.
(i)
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