LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
GLP: Yes [X] No [ ] ? [ ]
Test substance: Alkylbenzene sulfonate, sodium salt (designated as P-500 N-Na). activity
47%. Average alkyl chain length = C11.2. Yellow, viscous liquid.
Remarks: There were no deaths or signs of a systemic reaction following a single
dermal application at 2000 mg/kg bw. Well defined or slight erythema and
slight oedema were observed at all test sites after removal of the occlusive
dressing on Day 2. All test sites were entirely covered by scab formation
from Day 7. Sloughing from the scabbed skin began at various times
between Day 7 and Day 12 and was completed before termination. Low
bodyweight gains or loss of body weight were recorded for one male and
three females in Day 8. Two of the same females and a third female also
showed low bodyweight gain between Days 8 and 15.
Reference: Kynoch, S.R. 1986b. Acute dermal toxicity to rats of P-500 N-Na.
Huntingdon Research Center. Report No. 86718D/PEQ 8/AC.
Reliability: 1 Valid without restriction
(b)
Type: LD0 [ ]; LD100 [ ]; LD 50 [X]; LDL0 [ ]; Other [ ]
Species/strain: New Zealand white rabbit
Value: > 200 mg/kg and < 316 mg/kg
Method: Acute Skin Absorption Minimal Lethal Dose Test
The test substance was applied as a 30% aqueous solution and the doses of
the solution administered were 126, 200, 316, 501, 794, 1260, 2000, 3160
and 5010 mg/kg. The doses were administered to a closely clipped area of
intact skin of male and female rabbits (1 animal/dose). The treated areas
were covered with plastic strips and the animals were placed in wooden
stocks for up to twenty-four hours. After the twenty-four hours the animals
were assigned to individual cages. Observations of toxic signs were recorded
daily and the viscera of the test animals were examined macroscopically.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-225; C9 1%; C10 7%, C11
25%, C12 48%, C13 19%, C14 1%; average alkyl chain length = C11.9)
Remarks: The test substance was classified as moderately toxic. Animals exposed
dermally to 126 and 200 mg/kg survived for the 14 day study duration.
Survival time for animals receiving all other doses ranged from two to eight
days. The toxic signs included reduced appetite and activity, increasing
weakness, collapse and death. The autopsy revealed hemorrhagic lungs, liver
discoloration, enlarged gall bladder, and gastrointestinal inflammation. The
animals that survived were sacrificed fourteen days after dosing. In these
animals the viscera appeared normal by macroscopic examination.
Reference: Monsanto Company. 1971. Linear alkylbenzene sodium sulfonate –
Alkylate 225 Lot CC 6450 – Acute toxicity screen. Project No. Y-71-119.
Unpublished report.
Reliability: 4 (insufficient animals per dose of mixed sex, etc.)
(c)
Type: LD0 [ ]; LD100 [ ]; LD 50 [X]; LDL0 [ ]; Other [ ]
Species/strain: New Zealand white rabbit
Value: > 631 mg/kg and < 1000 mg/kg
Method: Acute Skin Absorption Minimal Lethal Dose Test
The test substance was applied as a 20% aqueous solution and the doses of
the solution administered were 200, 316, 631, 1000, 1260, 2000 and 3160
mg/kg. The doses were administered to a closely clipped area of intact skin
of male and female rabbits (1 animal/dose). The treated areas were covered
with plastic strips and the animals were placed in wooden stocks for up to
twenty-four hours. After the twenty-four hours the animals were assigned to
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