LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Method: OECD Guide-line 401 "Acute Oral Toxicity" 1981. Five male and five
female rats were given LAS doses of 1190, 1500 and 1890 or a control by
gavage. Body weight and other signs were measured on days 7 and 14.
Temperature was maintained at 20 + /-1 o C with a 12 hr light-dark cycle.
Animals were observed for 14 days after dosing.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Marlon A 330 (CAS #68411-30-3) C10-13 LAS, average alkyl chain length =
C11.6; Activity: 30%.
Remarks: Symptoms beginning about 90 minutes past application included diarrhea,
squatting attitude, breathing difficulties, nose bleeding, ataxia, and lethargy.
These symptoms had disappeared in surviving animals by 72 hours.
Virtually all animals died in doses of 1500 mg/kg and above. Note that all
doses are corrected for 30% activity. The original doses were 3980, 5010
and 6310 mg/kg.
Reference: Murmann, P. 1984a. Akute orale Toxizitat von Marlon A 330 fur Ratten.
Huels Report No. 0186.
Reliability: 2 Valid with restrictions
(d)
Type: LD0 [ ]; LD100 [ ]; LD 50 [X]; LDL0 [ ]; Other [ ]
Species/strain: rat
Value: LD50 for male animals: 1460 mg/kg
LD50 for female animals: 1470 mg/kg
Method: Male and female rats were given a single dose of LAS by gavage and
observed for mortality.
GLP: Yes [ ] No [X] ? [ ]
Test substance: C10-13 LAS, sodium salt (CAS #68411-30-3)