LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Reference: Debane, C. 1978. National Hygiene Laboratory; in: "Report on Studies on
Synthetic Detergents", October 1978, Japan's Science and Technology
Agency [in Japanese].
Reliability: 4 Not assignable
(b)
Type: Toxicokinetics
Method: The absorption, distribution, metabolism and elimination of LAS
(radioactively labelled with 35 S) were studied in male Charles River rats.
LAS was administered as an aqueous solution.
Results: The compound was readily absorbed from the gastrointestinal tract (80-90%
of the dose). Most of the absorbed 35 S was eliminated within 72 hours and
60-65% of the absorbed dose was eliminated in the urine, with sulfophenyl
butanoic and sulfophenyl pentatonic acid as metabolites. These metabolites
were not reabsorbed from the kidney tubules. 35% of the absorbed 35 S was
excreted in the bile and were reabsorbed completely from the gastrointestinal
tract. Although the metabolites in the bile were not identified, it was shown
that no unchanged LAS was eliminated via this pathway.
Test substance: C10-13, LAS (CAS #68411-30-3); alkyl chain length predominately C11, C12
and C13.
Remarks: The authors suggested that metabolism proceeded via omega oxidation with
subsequent beta-oxidation. Retention of radioactivity was not observed in
any organ.
Reference: Michael, W.R. 1968. Metabolism of linear alkylate sulfonate and alkyl
benzene sulfonate in albino rats. Toxicol. Appl. Pharmacol. 12:473-485.
Reliability: 2 Valid with restrictions
(c)
Type: Toxicokinetics
Results: LAS is well absorbed by via the gastrointestinal tract of pigs treated with 3.3
mmol/animal 35S-Na-dodecylbenzene sulfonate. At 200 hours after oral
administration, the radioactivity was relatively high in bristles and bones,
while low in liver, kidney and spleen. After 10 weeks only traces of
radioactivity were still in the body. 40 hours after the administration, 40% of
the dose was excreted into the urine and 60% of the dose via the faeces.
Remarks: Information as cited in the IUCLID Data Sheet and the IPCS document.
Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs.,
sodium salts. Year 2000 CD-ROM edition.
2) Havermann, H. and Menke, K.H. 1959. Biological study of the watersoluble
surface-active substances. Fette. Seifen. Anstrichmittel 61:429-434.
(in German); cited in IPCS. 1996. Environmental Health Criteria 169:
Linear Alkylbenzene Sulfonates and Related Compounds. World Health
Organization, Geneva, Switzerland. Original article in Japanese.
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document.
(d)
Type: Toxicokinetics
Results: Four (2 male, 2 female; 5 kg average body weight) adult rhesus monkeys
(Macaca mulatta) were given single or repeated oral (30, 150 or 300 mg/kg)
or subcutaneous (0.1, 0.5 or 1 mg/kg) doses of 14 C-LAS. After single 30
mg/kg oral doses the radioactivity was rapidly excreted, mostly during the
first 24 hours. Means of 71.2% and 23.1% of the dose were excreted in the
urine and feces, respectively, during 5 days. Similarly, after single 1 mg/kg
subcutaneous doses, means of 64.1% and 10.9% were excreted in urine and
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