LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ];
Irritating [X]; Moderate irritating [ ]; Slightly irritating [ ];
Not irritating [ ]
Classification: Irritating [X]; Not irritating [ ]; Risk of serious damage to eyes [ ]
Method: OECD Guide-line 405 "Acute Eye Irritation/Corrosion" 1981
GLP: Yes [ ] No [X] ? [ ]
Test substance: Marlon A 350 (CAS #68411-30-3) C10-13 LAS, average alkyl chain length =
C11.6; activity: 50%.
Remarks: The mean irritation index was 26.5 out of 110. Individual scores:
1.0; iris: 0; conjunctivae chemosis: 1.11, conjunctivae redness: 2.39
Reference: Murmann, P. 1983b. Prufung der akuten Augen-und Schleimhautreiz
Wirkung von Marlon A 350. Huels Report No. 0172.
Reliability: 2 Valid with restrictions
(d)
Species/strain: rabbit
Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ];
Irritating [X]; Moderate irritating [ ]; Slightly irritating [ ];
Not irritating [ ]
Classification: Irritating [X]; Not irritating [ ]; Risk of serious damage to eyes [ ]
Method: OECD Guide-line 405 "Acute Eye Irritation/Corrosion" 1984
GLP: Yes [X] No [ ] ? [ ]
Test substance: LAS
Remarks: Possibility of persistent effects on the eye.
Reference: Kaestner, W., Henkel KGaA, unpublished data, Report No. 870553 (1987).
Reliability: 4 Not assignable
(e)
Species/strain: rabbit
Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ];
Irritating [X]; Moderate irritating [ ]; Slightly irritating [ ];
Not irritating [ ]
Classification: Irritating [X]; Not irritating [ ]; Risk of serious damage to eyes [ ]
Method: 0.1 mL solutions of LAS at 5 different concentrations ranging from 0.01 to
1.0 % were instilled in the eyes of rabbits (13 per group). The rabbits were
observed for 24 hours after LAS application.
GLP: Yes [ ] No [X] ? [ ]
Test substance: C10-13 LAS, (CAS #68411-30-3). Molecular weight 346.5; average alkyl
chain length = C11.9
Remarks: Information as cited in IPCS document. The 0.01 % group showed no
abnormalities, but the 0.05 % group showed slight congestion. The groups of
0.5 % and higher concentrations showed marked reactions such as severe
congestion and oedema, increased secretion, turbidity of the cornea, and
disappearance of corneal reflex.
Reference: Oba, K., Mori, A. and Tomiyama, S. 1968. Biochemical studies of n-alphaolefin
sulfonates (II) Acute toxicity, skin and eye irritation, and some other
physical properties. Journ. Jap. Oil Chem. Soc. 17:628-634. (In Japanese)
cited in: IPCS (1996); Environmental Health Criteria 169: Linear
Alkylbenzene Sulfonates (LAS) and Related Compounds. WHO, Geneva,
Switzerland.
Reliability: 4 This study is assigned a reliability score of 4 because the original report
was not available for review. However, the study was evaluated by IPCS
prior to inclusion in their criteria document.
(f)
Species/strain: rabbit
UNEP PUBLICATIONS 266