LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) Test substance: LAS; mean molecular weight 348; average alkyl chain length = C12.0. Remarks: Information as cited in the IUCLID Data Set and the IPCS document. Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts. Year 2000 CD-ROM edition. 2) Endo, T., Furuido, Y., Namie, K., Yamamoto, N., Hasunuma, H. and Ueda, K. 1980. Studies of the chronic toxicity and teratogenicity of synthetic surfactants. Ann. Rep. Tokyo Metrop. Res Inst. Environ. Prot. 236-246 (in Japanese); cited in: IPCS (1996); Environmental Health Criteria 169: Linear Alkylbenzene Sulfonates (LAS) and Related Compounds. WHO, Geneva, Switzerland. Reliability: 4 This study is assigned a reliability score of 4 because the original report was not available for review. However, the study was evaluated by IPCS prior to inclusion in their criteria document. 5.9 DEVELOPMENTAL TOXICITY/ TERATOGENICITY (a) Species/strain: Rat (Wistar) and Rabbit (NZW) Sex: Female [X]; Male [ ]; Male/Female [ ]; No data [ ] Administration: drinking water Exposure period: day 6-15 of pregnancy (rat); day 6-18 of pregnancy (rabbit) Frequency of treatment: Daily Doses: 0.1% (70 mg/kg bw d in rat; 250 mg/kg bw d in rabbit) Control group: Yes [X]; No [ ]; No data [ ]; Concurrent no treatment [ ]; Concurrent vehicle [ ]; Historical [ ] NOAEL Maternal Toxicity: Rat > 0.1% (383 mg/rat); rabbit = 0.1% (3030 mg/rabbit). NOAEL teratogenicity: 0.1% for rat. LOAEL teratogenicity: 0.1% (3030 mg/rabbit) Results: The only effect on the dams was a slight inhibition of body weight gain in the rabbits. The litter parameters of both species did not show any significant differences from those of the controls. Delayed ossification was observed in rabbits, but there was no increase in malformations in either the rabbits or the rats. Method: LAS was given to 40 rats (20 controls) and 22 rabbits (11 controls) from day 6 to 15 (rats) and day 6 to 18 (rabbits) of pregnancy, respectively. GLP: Yes [ ] No [X] ? [ ] Test substance: LAS; activity: 38.74%; average alkyl chain length = C12.0; (mean molecular weight 348) Remarks: Information as cited in the IUCLID Data Set and the IPCS document. Reference: 1) European Commission. 2000a. Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts. Year 2000 CD-ROM edition. 2) Endo, T., Furuido, Y., Namie, K., Yamamoto, N., Hasunuma, H. and Ueda, K. 1980. Studies of the chronic toxicity and teratogenicity of synthetic surfactants. Ann. Rep. Tokyo Metrop. Res. Inst. Environ. Prot. 236-246 (in Japanese); cited in: IPCS (1996); Environmental Health Criteria 169: Linear Alkylbenzene Sulfonates (LAS) and Related Compounds. WHO, Geneva, Switzerland. Reliability: 4 This study is assigned a reliability score of 4 because the original report was not available for review. However, the study was evaluated by IPCS prior to inclusion in their criteria document. (b) Species/strain: Rat: CD Sex: Female [X]; Male [ ]; Male/Female [ ]; No data [ ] UNEP PUBLICATIONS 290
OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) Administration: gavage Duration of the test: sacrifice at day 20 of gestation Exposure period: day 6 - 15 of pregnancy Frequency of treatment:daily Doses: 0.2, 2, 300, 600 mg/kg bw d Control group: Yes [X]; No [ ]; No data [ ]; Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ] NOAEL Maternal Toxicity: 300 mg/kg bw NOAEL teratogenicity: 600 mg/kg bw Results: Maternal toxicity: Body weight gain was retarded in the highest dose group from the start of dosing and showed partial recovery toward the end of the dosing period. One animal died in this group but it could not be conclusively related to treatment. The toxic effects were associated with disturbance of the gastrointestinal tract. Pregnancy rate was comparable at all dosages. Teratogenicity: No differences were observed among dose groups and the control group with respect to number of litters, viable young, litter weight, foetal weight, embryonic deaths, implantations, corpora lutea, pre- and post implantation embryonic loss, major malformations, minor visceral or embryonic loss, major malformations, minor visceral or skeletal anomalies or incidence of pups with extra ribs. Method: Animals received doses by gavage daily from days 6-15 of gestation. Twenty animals per dose group were used. GLP: Yes [ ] No [X] ? [ ] Test substance: LAS Reference: Palmer, A.K., Readshaw, M.A. and Neuff, A.M. 1975a. Assessment of the teratogenic potential of surfactants (Part I) – LAS, AS and CLD. Toxicology 3:91-106. Reliability: 2 Valid with restrictions (c) Species/strain: Charles River CD strain rat Sex: Female [X]; Male [ ]; Male/Female [ ]; No data [ ] Administration: Oral in distilled water Duration of the test: 20 days Exposure period: day 6 to day 15 of pregnancy Frequency of treatment:daily Doses: 0.2, 2.0, 300 and 600 mg/kg Control group: Yes [X]; No [ ]; No data [ ]; Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ] NOAEL Maternal: 300 mg/kg NOAEL teratogenicity: 300 mg/kg Results: Maternal toxicity: Parent animals were observed daily. Change in bodyweight was not affected by treatment at 0.2, 2.0, and 300 mg/kg, but treatment at 600 mg/kg was associated with retarded weight gain and a transient diarrhea following initiation of treatment. The pregnancy rate was comparable at all dosages. Pregnancy/litter data: The litter parameters assessed included litter size, fetal loss and litter weight. These parameters were not significantly affected by any dosage. Mean pup weights were statistically higher at 0.2, 2.0 and 300 mg/kg. Teratogenicity: Embryonic and fetal development were assessed by the incidence of major malformations. The incidence of minor visceral anomalies was unaffected by treatment at any dosage. The distribution of UNEP PUBLICATIONS 291
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LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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