LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) (b) Type: Guinea pig maximisation test Species/strain: guinea pig, females Results: Sensitising [ ]; Not sensitising [X]; Ambiguous [ ] Classification: Sensitising [ ]; Not sensitising [X] Method: OECD Guide-line 406 "Skin Sensitisation" 1981 GLP: Yes [ ] No [X] ? [ ] Test substance: Marlon A 350 (CAS #68411-30-3) C10-13 LAS, average alkyl chain length = C11.6; activity: 50%. Remarks: 0.1% intracutaneous and 3% epidermal doses. No sensitizing effects were observed. Reference: Murmann, P. 1988. Prufung auf hautsensibilisierende Wirkung am Meerschweinchen von Marlon A 350. Huels Report No. 1387. Reliability: 2 Valid with restrictions (c) Type: Maximization test Species/strain: Guinea pig, Hartley Results: Sensitising [ ]; Not sensitising [X]; Ambiguous [ ] Classification: Sensitising [ ]; Not sensitising [X] Method: OECD Guideline 406, 1981; Directive 179/831 Annex, Part B. GLP: Yes [X] No [ ] ? [ ] Test substance: LAS, activity: 50%; average alkyl chain length = C11.6 Remarks: Solutions of LAS were applied intracutaneously and epicutaneously to 10 male and 10 female animals. Induction concentration was 25% in water; the challenge concentration was 12.5%. No positive responses were observed. Reference: RBM. 1985. Test di sensibilizzazione cutanea nella cavia. RBM Exp. No. 2076. Reliability: 1 Valid without restriction 5.4 REPEATED DOSE TOXICITY (a) Species/strain: Rat (FDRL) Sex: Female [ ]; Male [ ]; Male/Female [X]; No data [ ] Administration: Oral feed Exposure period: 12 weeks Dose: 50 or 250 mg/kg bw d Control group: Yes [X]; No [ ]; No data [ ]; Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ] NOAEL: 50 mg/kg bw d LOAEL: 250 mg/kg bw d Results: No behavioural abnormalities were noted during the test period. Growth responses were equal in all groups. There were no differences in food intake or in efficiency of food utilization. The clinical data showed no abnormal variations in any of the dose groups. The relative organ weights and the histopathological evaluation did not show significant differences among the dose groups except a liver weight increase in female animals of the high dose group. Method: Based on Fitzhugh and Schouboe (1959) Subacute toxicity in: Assoc. Food Drug Offices of the U.S., Austin, Texas, p. 26-35. Weanling rats were distributed into 5 groups of 15 male and 15 female animals per dose group. All rats were given standard diet daily. Doses were 0, 50 and 250 mg/kg bw d in the diet. Daily observations of behavior and signs of toxicity were made. Food consumption and blood and urine chemistries were also measured UNEP PUBLICATIONS 270
OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) periodically. Organ weights and gross pathological findings were measured at the end of the study in the liver, kidneys, spleen, heart, adrenals, pituitary, and cecum. GLP: Yes [ ] No [X] ? [ ] Test substance: C10-13 LAS, sodium salt, activity: 39.5%; average molecular weight 346; average alkyl chain length = 11.9 Reference: Oser, B.L. and Morgareidge, K. 1965. Toxicological studies with branched and linear alkyl benzene sulfonates in rats. Toxicol. Appl. Pharmacol. 7:819- 825. Reliability: 2 Valid with restrictions (b) Species/strain: rat (Sprague-Dawley) Sex: Female [ ]; Male [ ]; Male/Female [X]; No data [ ] Administration: oral feed Exposure period: 90 days Frequency of treatment: Ad libitum Dose: 0.02/0.1/0.5% (corresponding to 8.8, 44 and 220 mg/kg bw d) Control group: Yes [X]; No [ ]; No data [ ]; Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ] NOAEL: 0.5% (220 mg/kg bw d) Results: No adverse effects were found upon the following parameters: growth, food efficiency, survival, haematologic values, and urinary analytical values. In addition, no treatment-related adverse effects were observed in absolute and relative organ weights, nor were gross histopathological changes observed in any of the organs examined. Method: Groups of 10 male and 10 female weanling rats were fed levels of 0.02, 0.1 or 0.5% LAS in a commercial chow for 90 days. Body weights, food consumption, mortality, and several blood parameters were measured periodically during the study and at termination. Autopsy and microscopic examination of the organs was performed at test termination. Organ weights and gross pathological findings were recorded for the liver, kidneys, spleen, gonads, heart, and brain. GLP: Yes [ ] No [X] ? [ ] Test substance: C10-14 LAS, sodium salt (CAS #69669-44-9), activity: 87.9%; C10 1.8%, C11 43.2%, C12 32.2%, C13 16.0%, C14 5.3%, C15 1.5%; average alkyl chain length = C11.8; mean molecular weight 346. Remarks: Two male rats at the 0.2% level died in the early stages of the study. These deaths were attributed to respiratory illness and were not considered to be treatment related. Reference: Kay, J.H., Kohn, F.E. and Calandra, J.C. 1965. Subacute oral toxicity of a biodegradable linear alkylbenzene sulfonate. Toxicol. Appl. Pharmacol. 7:812-818. Reliability: 2 Valid with restrictions (c) Species/strain: Rat/Sprague-Dawley Sex: Female [ ]; Male [ ]; Male/Female [X]; No data [ ] Administration: gavage Exposure period: one month Frequency of treatment: daily Dose: 125, 250, 500 mg/kg bw d. Control group: Yes [X]; No [ ]; No data [ ]; Concurrent no treatment [X]; Concurrent vehicle [ ]; Historical [ ] NOAEL: 125 mg/kg bw d LOAEL: 250 mg/kg bw d UNEP PUBLICATIONS 271
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