LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Remarks: The compound was classified as mildly toxic by oral ingestion in male and
female rats. All rats survived at 1000 mg/kg. Three of 5 and 2 of 5 survived
1260 and 1580, respectively. Survival time was sixteen hours to two days in
the rats that died. The toxic signs included reduced appetite and activity (two
to three days in survivors), increasing weakness, slight tremors, collapse, and
death. The autopsy revealed lung and liver hyperaemia and gastrointestinal
inflammation. Surviving animals were sacrificed seven days after dosing. In
these animals the vircera appeared normal by macroscopic examination.
Reference: Monsanto Company. 1972a. Linear alkylbenzene sodium sulfonate –
Alkylate 215 Lot CC 6772S – Acute toxicity screen. Project No. Y-72-274.
Unpublished report.
Reliability: 2 Valid with restrictions
(h)
Type: LD0 [ ]; LD100 [ ]; LD 50 [X]; LDL0 [ ]; Other [ ]
Species/strain: Sprague-Dawley strain albino male and female rats
Value: 1360 mg/kg (lower limit: 1240 mg/kg; upper limit: 1500 mg/kg)
Method: Acute Oral Minimal Lethal Dose Test
The test substance was applied as a 10% aqueous solution by stomach tube to
Sprague-Dawley strain albino male and female rats. After the approximate
LD50 was determined, groups of male and female rats were fed in increasing
doses at increments of 0.1 fractional log intervals at four levels (1000, 1260,
1580 and 2000 mg/kg) designed to blanket the toxicity range thereby
supplying data for calculation of the LD50 which was performed according to
the method of E.J. de Beer. Observations of toxic signs were recorded and
the viscera of the test animals were examined macroscopically.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-222L); average alkyl
chain length = C11.5
Remarks: The compound was classified as slightly toxic by oral ingestion in male and
female rats. Survival time was sixteen hours to three days in the rats that
died. The toxic signs included reduced appetite and activity (one to three
days in survivors), increasing weakness, collapse, and death. The autopsy
revealed lung and liver hyperaemia and gastrointestinal inflammation.
Surviving animals were sacrificed seven days after dosing. In these animals
the vircera appeared normal by macroscopic examination.
Reference: Monsanto Company. 1972b. Linear alkylbenzene sodium sulfonate –
Alkylate 222L Lot CC 6773S – Acute toxicity screen. Project No. Y-72-275.
Unpublished report.
Reliability: 2 Valid with restrictions
(i) (Mouse)
Type: LD0 [ ]; LD100 [ ]; LD 50 [X]; LDL0 [ ]; Other [ ]
Species/strain: mouse
Value: LD50 male animals: 2160 mg/kg
LD50 female animals: 2250 mg/kg
Method: Male and female mice were given a single dose of LAS and observed for
mortality.
GLP: Yes [ ] No [X] ? [ ]
Test substance: C10-13 LAS, sodium salt (CAS #68411-30-3).