LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Reference: Monsanto Company. 1972a. Linear alkylbenzene sodium sulfonate –
Alkylate 215 Lot CC 6772S – Acute toxicity screen. Project No. Y-72-274.
Unpublished report.
Reliability: 2 Valid with restrictions
(k)
Species/strain: albino male and female rabbits
Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [ ];
Irritating [ ]; Moderate irritating [ ]; Slightly irritating [X];
Not irritating [ ]
Classification: Irritating [X]; Not irritating [ ]; Risk of serious damage to eyes [ ]
Method: A total of 100 mg of finely ground sample was administered in the
conjunctival sac of the right eye of each of three albino male and female
rabbits. Observations for inflammation were made over seven days. The
treated eyes were washed with isotonic saline solution after the 24 hour
reading. The left eye served as a control. The data was scored according to
the method of Draize, et al. Tests were conducted in accordance with the
Federal Hazardous Substance Act.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-222L; average alkyl chain
length = C11.5)
Remarks: Moderate erythema and slight edema and a copious discharge were present
10 minutes after application. A slight erythema persisted for 72 hours after
which the eyes returned to normal. The average maximum score was 18 out
of a possible 110 after 24 hours. This compound is classified as a mild eye
irritant.
Reference: Monsanto Company. 1972b. Linear alkylbenzene sodium sulfonate –
Alkylate 222L Lot CC 6773S – Acute toxicity screen. Project No. Y-72-
275. Unpublished report.
Reliability: 2 Valid with restrictions
5.3 SKIN SENSITIZATION
(a)
Type: Sensitisation test
Species/strain: Guinea pig (males & females, albino)
Results: Sensitising [ ]; Not sensitising [X]; Ambiguous [ ]
Classification: Sensitising [ ]; Not sensitising [X]
Method: Buehler Test; OECD Guideline 406 "Skin Sensitization" 1981; Directive
84/449, EEC B.6. "Acute Toxicity - Skin Sensitization".
GLP: Yes [X] No [ ] ? [ ]
Test Substance: LAS; activity: 6.7%; average alkyl chain length = C11.6
Remarks: The purpose of this study was to assess the allergenic potential of LAS when
administered to the skin. 10 animals (5M/5F) remained untreated and were
used as controls to be treated at first challenge. 10 animals (5M/5F)
remained untreated and were used as additional controls to be treated at
second challenge; 20 animals (10M/10F) were treated with LAS. Induction
concentration was 1.0% in water; first and second challenge concentrations
were 0.8% in water. 0/20 animals responded in the treated group; 0/10
animals responded in the control group.
Reference: European Commission. 2000o. Benzenesulfonic acid, C10-13-alkyl derivs.,
sodium salts. Year 2000 CD-ROM edition, citing The Procter & Gamble
Company, unpublished data, Reports No. RCC-2315547.
Reliability: 4 Not assignable
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