LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
Table 7. Results from Developmental Toxicity Studies on LAS
Animal Route
Oral Exposure
Rat Drinking
water
Rat Drinking
water
Exposure in
Pregnancy
NOAEL
Maternal
(mg/kg
bw/day)
NOAEL
Fetal
(mg/kg
bw/day)
Doses
(mg/kg
bw/day)
Reference
Days 6-15 70 70 70 Endo et al. 1980
Days 6-15 300 300 0.2, 2, 300,
600
Rat Gavage Days 6-15 300 600 0.2, 2, 300,
600
Rat Oral feed Continuous or
Days 6-15
225 225 22.5, 112.5,
225
Palmer & Lovell
1971a
Palmer et al. 1975a
Nolen et al. 1975
Rat Oral feed Days 0-20 780 780 80, 780 Tiba et al. 1976
Mouse Drinking
water
Days 6-15 2 600 0.2, 2, 300,
600
Mouse Gavage Days 6-15 2 300 0.2, 2, 300,
600
Mouse Gavage Days 0-6 or
Days 7-13
Palmer & Lovell
1971b
Palmer et al. 1975a
40 400 40, 400 Takahashi et al.
1975
Mouse Gavage Days 6-15 10 300 10, 100, 300 Shiobara & Imahori
1976
Rabbit Drinking
water
Days 6-18 250
(LOAEL)
250
(LOAEL)
Rabbit Gavage Days 6-18 2 2 0.2, 2, 300,
600
250 Endo et al. 1980
Palmer et al. 1975a;
Palmer and Neuff
1971
Rabbit Oral feed Days 2-16 135 135 22.5, 45, 135 Nolen et al. 1975
Dermal Exposure
Rat Dermal Days 2-15 6 60 0.6, 6, 60 Palmer et al. 1975b
Rat Dermal Days 0-21 20 400 0.1, 2, 10, 20,
100, 400
Daly et al. 1980
Mouse Dermal Days 2-13 5 50 5, 50, 500 Palmer et al. 1975
Mouse Dermal Days 0-13 110 110 110 Sato et al. 1972
Mouse Dermal Days 6-15 150 1500 15, 150, 1500 Imahori et al. 1976
Mouse SC Injection Days 0-3 or 8-
11
20 200 20, 200 Takahashi et al.
1975
Rabbit Dermal Days 1-16 0.9 90 0.9, 9, 90 Palmer et al. 1975b
3.2 Initial Assessment for Human Health
Substantial data exist for mammalian toxicity. The available data indicate that LAS exhibits slight
acute toxicity. Oral LD50 values for rats range from 1,080 to 1,980 mg/kg bw. Oral LD50 values for
mice are 2,160 and 2,250 mg/kg bw for males and females, respectively. The rat dermal LD50 value
was greater than 2,000 mg/kg bw. The oral and dermal acute toxicity data for LAS generally
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