LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS)
GLP:
impermeable covering. The patch is removed after a 4 hour exposure and the
site washed with water. A second site with the skin abraded received the
same treatment. Animals are examined for signs of erythema and oedema
and the responses scored at 60 minutes, 24, 48 and 72 hr, and daily as needed
up to 7 days. Skin irritation is scored using the standard rating system and
averaged.
Yes [ ] No [X] ? [ ]
Test substance: LAS (made from Sirene LAB); activity 1%; average alkyl chain length =
C11.6
Remarks: No signs of irritation were observed during the study.
Reference: Biolab SGS. 1983. Primary skin irritation. Report No. T116/2.
Reliability: 2 Valid with restrictions
(h)
Species/strain: albino male and female rabbits
Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [X];
Irritating [ ]; Moderate irritating [ ]; Slightly irritating [ ];
Not irritating [ ]
Classification: Highly corrosive (causes severe burns) [ ];
Corrosive (causes burns) [ ]; Irritating [X]; Not irritating [ ]
Method: The clipped, intact and abraded skin of six albino male and female rabbits
was exposed to 0.5 g of finely ground sample moistened with water under a
one inch by one inch square patch, two single layers thick. The patches were
positioned in place with adhesive tape. The trunk of each animal was
wrapped with plastic strips to avoid contamination and retard evaporation for
the 24 hour exposure period. Observations were made over a period of seven
days for irritation. The data was scored according to the method of Draize,
et al.
GLP: Yes [ ] No [X] ? [ ]
Test substance: Sodium sulfonate of linear alkylbenzene (Alkylate-225); C9 1%, C10 7%, C11
25%, C12 48%, C13 19%, C14 1%; average alkyl chain length = C11.9
Remarks: Primary Irritation Score: 6.2
Intact Skin: 6.8/8
Abraded Skin: 6.8/8
Slight to moderate erythema and edema were present after 24 hours. These
symptoms persisted through 120 hours. The compound was classed as a
primary skin irritant under the grading system as outlined in the Federal
Hazardous Substance Act. The sample had a defatting effect on the skin
causing the skin to slough off in ten to fourteen days. There was no injury in
depth.
Reference: Monsanto Company. 1971. Linear alkylbenzene sodium sulfonate –
Alkylate 225 Lot CC 6450 – Acute toxicity screen. Project No. Y-71-119.
Unpublished report.
Reliability: 2 Valid with restrictions
(i)
Species/strain: New Zealand white male and female rabbits
Results: Highly corrosive [ ]; Corrosive [ ]; Highly irritating [X];
Irritating [ ]; Moderate irritating [ ]; Slightly irritating [ ];
Not irritating [ ]
Classification: Highly corrosive (causes severe burns) [ ];
Corrosive (causes burns) [ ]; Irritating [X]; Not irritating [ ]
Method: The clipped, intact and abraded skin of three New Zealand white male and
female rabbits was applied with 0.5 g of finely ground sample moistened
with water under a one inch by one inch square patch, two single layers
thick. The patches were positioned in place with adhesive tape. The trunk of
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