LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) Annex 2 – Commercial LAS (C11.6 – C11.8) Acute Toxicity Data This Annex provides the results of an extensive review of the data previously compiled by BKH (1993) and of the published and unpublished literature since this data compilation (HERA 2004). The purpose of this review is to identify the lowest valid acute toxicity values on commercially representative LAS, having average alkyl chain lengths of C11.6 to 11.8 (Table, SIAR Section 1.1). Valid studies on commercial LAS on test species for which there are OECD acute toxicity guidelines are listed in the tables below. References to the published studies follow the tables. Studies that were not valid, or were not conducted on commercial LAS, are listed in the table of rejected studies along with the reasons for rejection. Lowest valid values for each taxon are identified in the table. Robust summaries of these studies are included in the dossier. The location of other studies provided in the dossier are noted under Remarks. Note that all non GLP studies date before the implementation of OECD GLP guidelines. Studies noted as QA are those whose report mentioned a specific Quality Assurance program. UNEP PUBLICATIONS 92
OECD SIDS LINEAR ALKYLBENZENE SULFONATE (LAS) Fish, 96h. Lepomis macrochirus Reference and year 1. 22852, P&G 1979 2. 23613,P&G 1980 3. 23612, P&G 1980 4. 23617, P&G 1980 5. 23722, P&G 1980 6. 22824, P&G 1978 7. 28661, P&G 1982 8. 27917, P&G 1980 LC50 (mg/L) 3.7 4.4 4.6 4.6 4.6 6.3 6.4 7.7 Lab Test Procedure Bionomics UCES Bionomics Bionomics UCES UCES Biospherics Bionomics US EPA 1975 EPA-660/3- 75-009 US EPA 1975 EPA-660/3- 75-009 US EPA 1975 EPA-660/3- 75-009 US EPA 1975 EPA-660/3- 75-009 US EPA 1975 EPA-660/3- 75-009 US EPA 1975 EPA-660/3- 75-009 US EPA 1975 EPA-660/3- 75-009 US EPA 1975 EPA-660/3- 75-009 GLP Static/flow through QA QA QA QA QA No QA No Static Static Static Static Static Static Static Static # replicates Indiv./rep. Nominal conc (mg/L) 3 Not reported 3 3 5 Nortreported Nortreported 3 10 10 10 10 10 10 10 10 Control, 1.3, 2.2, 3.6, 6.0, 10 Control, 0.86, 1.4, 2.4, 4.0, 6.7 Control, 0.78, 1.3, 2.2, 3.6, 6.0, 10 Control, 0.78, 1.3, 2.2, 3.6, 6.0, 10 Control, 1.0, 1.8, 3.2, 5.6, 10 Control, 1.4, 2.2, 3.6, 6.0, 10 Control, 01.3, 2.2, 3.6, 6.0, 10 Control, 1.3, 2.2, 3.6, 6.0, 10 Test T range (ºC) 22±1 20-23 22±1 22±1 21-22 22±0.5 21-22 22±1 Hard. (mg CaCO3/L) 43 30 48 45 38 46 47 42 Measured conc. Nominal conc active Nominal conc active Nominal conc active Nominal conc active Nominal conc active Nominal conc active Nominal conc active Nominal conc active Control mortality Remarks/deviation from protocol UNEP PUBLICATIONS 93 0% 0% 0% 0% 0% 0% 0% 0% 6 and 10 mg/L solutions were cloudy; dossier 4.1(m) Dossier 4.1(m) 6 and 10 mg/L solutions were cloudy; dossier 4.1(m) Dossier 4.1(m) Dossier 4.1(m) Dossier 4.1(m) Dossier 4.1(m) 10 mg/L solution was cloudy; dossier 4.1(m)
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LINEAR ALKYLBENZENE SULFONATE (LAS) - UNEP Chemicals

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