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The exposure and toxicity of pesticides to amphibians

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Table 12: LD50 data from dosing studies on <strong>amphibians</strong>.<br />

Pesticide %<br />

a.i.<br />

Test<br />

material<br />

Species Stage Temp.<br />

°C<br />

Aldrin NR Tech. Rana<br />

Adult<br />

hexadactyla (55g)<br />

Aldrin NR Tech. Rana<br />

Adult<br />

hexadactyla (55g)<br />

Aldrin 30 Form. Rana tigrina Adult<br />

(40-<br />

60g)<br />

Aldrin 30 Form. Rana tigrina Adult<br />

(40-<br />

60g)<br />

Carbaryl 50 NR Rana<br />

catesbeiana<br />

Carbaryl NR NR Limnonectes<br />

limnocharis<br />

Exposure<br />

type<br />

Amphibians <strong>and</strong> <strong>pesticides</strong><br />

Supporting publications 2012:EN-343 83<br />

<strong>The</strong> present document has been produced <strong>and</strong> adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context <strong>of</strong> a contract between the European Food<br />

Safety Authority <strong>and</strong> the author(s), awarded following a tender procedure. <strong>The</strong> present document is published complying with the transparency principle <strong>to</strong> which the Authority is subject. It may not be considered as an<br />

output adopted by the Authority. <strong>The</strong> European food Safety Authority reserves its rights, view <strong>and</strong> position as regards the issues addressed <strong>and</strong> the conclusions reached in the present document, without prejudice <strong>to</strong> the<br />

rights <strong>of</strong> the authors.<br />

Dur.<br />

(h)<br />

Dose<br />

levels<br />

Anim.<br />

/dose<br />

LD50<br />

(mg/kg)<br />

(95%<br />

CL)<br />

27±2 Oral<br />

(intub.)<br />

27±2 Oral<br />

(intub.)<br />

19-20 Oral 24 13 10 75<br />

(66.6-<br />

85.4)<br />

Comments Reference<br />

24 6 10 2.2 Assume data based on<br />

active ingredient.<br />

48 6 10 2.5 Assume data based on<br />

active ingredient.<br />

19-20 Oral 48 13 10 41.4<br />

(33.1-<br />

51.7)<br />

NR NR Oral<br />

(capsule)<br />

Adult<br />

(1.8-<br />

2g)<br />

Dose described as<br />

formulation (Aldrin 30%<br />

EC). Data here is for<br />

active ingredient<br />

calculated assuming 30%<br />

active ingredient.<br />

Dose described as<br />

formulation (Aldrin 30%<br />

EC). Data here is for<br />

active ingredient<br />

calculated assuming 30%<br />

active ingredient.<br />

336 NR NR >4000 Basis <strong>of</strong> LD50 value<br />

unclear. Based on data for<br />

3 males. Toxicity <strong>to</strong> 3<br />

month old mallard<br />

>2564mg/kg. Toxicity <strong>to</strong><br />

2 month old Japanese<br />

quail 2290mg/kg.<br />

NR IP 96 9 10 125 Assuming values are for<br />

active ingredient.<br />

Carbaryl 50 Form. Rana tigrina Adult NR IP 96 NR NR 320 Calculated active<br />

ingredient LD50<br />

assuming 50% carbaryl.<br />

Joseph <strong>and</strong><br />

Rao (1990)<br />

Joseph <strong>and</strong><br />

Rao (1990)<br />

Srivastava et<br />

al (1988)<br />

Srivastava et<br />

al (1988)<br />

Hudson et al<br />

(1984)<br />

Krishnappa<br />

<strong>and</strong><br />

Venkateshwarl<br />

u (2007)<br />

Sampath <strong>and</strong><br />

Elango (1997)

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