Nestlé in society Creating Shared Value and meeting our commitments 2015

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Nestlé in society: Creating Shared Value Nutrition, health and wellness Rural development Water Environmental sustainability Human rights and compliance Our people Customer health and safety G4-DMA Our R&D units Role (and research themes) 2015 collaborations (internal and external) Consumer benefits Nestlé Research Center (NRC) Drives science and technology, from basic nutrition and health research to applied research for product development and application. • Collaboration with the EpiGen Global Research Consortium (EpiGen) to study the impact of maternal nutrition on maternal and infant health. • Collaboration with Soochow University, Suzhou, China, to conduct a meta-analysis to determine whether probiotic fermented milk has an effect on blood pressure. • Council of Scientific and Industrial Research and the Agricultural Research Council in South Africa on green leafy vegetables. • The Feeding Infants and Toddlers Study (FITS) and Kids Nutrition and Health Study (KNHS) are executed in collaboration with the following research partners: University of North Carolina and RTI International in North Carolina, USA; Chinese Centre for Disease Control and Prevention in Beijing; and the Russian Institute of Nutrition in Moscow. • NRC has worked on health economics studies in collaboration with the Food and Nutrition Research Institute in the Philippines and the Winterthur Institute of Health Economics in Switzerland on micronutrient fortification, and with Bocconi University in Italy and the Peking University in China in relation to gestational diabetes. Scientific publications/studies in 2015 include: • An article showing the development of gut microbiota in infants is influenced by external factors such as mode of birth and duration of gestation, and is related to body fat levels in later life; and • An article reporting that whole grain intake in pregnant women in Singapore is below the recommended guidelines. A study was launched in Singapore, New Zealand and the UK to assess the impact of nutrients before and during pregnancy on the health of mothers and their babies. • Study published on dairy consumption and the risk of cardiovascular disease. • In September 2015, Nestlé South Africa launched a new line of Maggi instant noodles with morogo, a local spinach that helps increase beta-carotene and vitamin A levels. • FITS and KNHS results published in 2015 indicate that breastfeeding rates in China and Mexico are below recommendations. Many Chinese children have low nutrient intakes, especially in rural areas, and many diets lack variety. In Mexico, young children are more likely to receive sweets than fruits or vegetables. Nestlé Clinical Development Unit (CDU) A central location for Nestlé’s clinical development programmes, established to evaluate the impact of our foods on human biology, health, taste and pleasure. • CDU works with the Clinical Data Interchange Standards Consortium (CDISC), in the United States, to drive the development of data standards for clinical research in collaboration with industry partners. • Our research with Medidata aims to develop innovative ways to gather health information that is relevant to our consumers. • Collaboration between CDU and Professor Shein-Chung Chow, Department of Biostatistics and Bioinformatics, Duke University, on adaptive design methods in clinical trials. • Increase data quality to support nutrition, health and wellness messages and support fast availability of products on the market. • Obtain the highest quality of objective evidence for the health benefits of our products. Nestlé in society – Creating Shared Value and meeting our commitments 2015 50
Nestlé in society: Creating Shared Value Nutrition, health and wellness Rural development Water Environmental sustainability Human rights and compliance Our people Customer health and safety G4-DMA Our R&D units Role (and research themes) 2015 collaborations (internal and external) Consumer benefits Nestlé Institute of Health Sciences (NIHS) Biomedical research institute specialising in metabolic health, gastrointestinal health, brain health and ageing. • Signed research collaboration agreement with leading Swiss biopharmaceutical company AC Immune in September 2015. • Began collaborative project with EpiGen to study sarcopenia at a molecular level. • The collaboration aims to develop a sensitive, minimally invasive procedure to map the early stages of Alzheimer’s disease by applying antibody technology provided by the NIHS. • Research will indicate how innovative nutritional therapies can be applied to sarcopenia sufferers. Key businesses Role (and research themes) 2015 collaborations (internal and external) Consumer/patient benefits Nestlé Health Science (NHSc) A wholly owned Nestlé subsidiary engaged in advancing the role of nutritional therapy to change the course of health for consumers, patients and our partners in healthcare. • Agreement signed with Lipid Therapeutics to deliver novel ulcerative colitis therapy. • Invested in Seres Therapeutics, to support phase III trials of SER-109 for the prevention of recurrent Clostridium difficile infection (CDI). The US Food and Drug Administration (FDA) granted SER-109 orphan drug, as well as a breakthrough therapy designation in 2015. www.serestheraputics.com In January 2016: NHSc and Seres signed licensing agreement (see Seres and/or NHSc website, newsroom). • Launched nutritional solutions such as Meritene® Mobilis (in Europe) and Boost® nutritional drinks in compact sizes (in the United States) to meet the special needs of the ageing body. • Launched the Compat Ella® feeding pump, which connects to patient data systems to ensure that feeding rates are easily adjusted to patient needs, thereby improving clinical outcomes and reducing care costs. • Launched CoMiSS®, an awareness tool to help primary healthcare professionals assess the likelihood of cow’s milk protein allergy with 80% effectiveness. Nestlé Skin Health A wholly owned Nestlé subsidiary focusing on meeting the world’s increasing skin health needs with a broad range of innovative and scientifically proven products. • Announced plans to build new SHIELD centres in Shanghai, China, and São Paulo, Brazil. • This global innovation network aims to foster breakthroughs and collaboration in skin health through medical investigation, education and applications. Nestlé Nutrition Institute (NNI) Shares leading science-based nutrition information and education with healthcare professionals, scientists, and public health communities and stakeholders. • In 2015, NNI supported 13 international congresses, holding satellite symposia at 9 of them. • Works with healthcare professionals. Nestlé in society – Creating Shared Value and meeting our commitments 2015 51
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