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Boli virotice si prionice ale animalelor - CYF MEDICAL DISTRIBUTION

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<strong>Boli</strong> produse de virusuri din fam. Retroviridae 621<br />

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27. Meas S., Usui, T., Ohashi, K., Sugimoto, C.,<br />

Onuma, M. (2002), Vet. Microbiol., 84(3):275<br />

28. Milhau, N., Bellaton, C., Balleydier, S., Gaonach,<br />

M., Le Jan, C. (2003), Vet. Res., May-Jun,<br />

34(3):273<br />

29. Mizuno, T., Goto, Y., Baba, K., Momoi, Y., Endo, Y.,<br />

Nishimura, Y., Masuda, K., Ohno, K., Tsujimoto, H.<br />

(2003), Vet. Immunol. Immunopathol., Jun 20;93(3-<br />

4):117<br />

30. Morin, T., Guiguen, F., Bouzar, B.A., Villet, S.,<br />

Greenland, T., Grezel, D., Gounel, F., Gallay, K.,<br />

Garnier, C., Durand, J., Alogninouwa, T., Mselli-<br />

Lakhal, L., Mornex, J.F., Chebloune, Y. (2003), J.<br />

Virol., 77(11):6430<br />

31. Murphy F.A., Gibbs E.P., Horzinek, C.M., Studdert,<br />

M.J. (1999), Veterinary Virology, Academic Press,<br />

Third Ed., San Diego, London, Boston, New York,<br />

Sydney, Tokyo, Toronto<br />

32. Paul, I. (1996), Etiomorfopatologie veterinară,<br />

Editura ALL, Bucureşti, vol.I<br />

33. Pepin, M., Vitu, C., Russo, P., Mornex, J.F.,<br />

Peterhans, E. (1998), Vet. Res., 29 (3-4):341<br />

34. Perk, K. (1995), Leukemia., 9 Suppl 1:898<br />

35. Post, K., Guo, J., Howard, K.J., Powell, M.D., Miller,<br />

J.T., Hizi, A., Le Grice, S.F., Levin, J.G. (2003), J.<br />

Virol., 77(13):7623<br />

36. Radostis, O.M., Gay, C.C., Blood, D.C., Hinchcliff,<br />

K.W. (2000), Veterinary medicine, 9th Edition, W.B.<br />

Saunders Company Ltd, London, New York,<br />

Philadelphia, San Francisco, St. Louis, Sydney<br />

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Montelaro, R.C. (2003), Virology, 311(1):169<br />

38. Russell, K.E., Walker, K.M., Miller, R.T., Sellon,<br />

D.C. (1998), Am. J. Vet. Res., 59(8):1009<br />

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(2000), J. Virol., 74(21):10096<br />

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K.F., Cooper, C.R., Hoyt P.G., Luther, D.G., Jenny,<br />

B.F. (2003), Comp. Immunol. Microbiol. Infect. Dis.,<br />

26(1):1<br />

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Cooper, C.R., Storts, R.W., Luther, D.G., Jenny,<br />

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5):1301<br />

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Infect. Dis., 27(1):1<br />

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D.F., McLean, C.A., Preiss, S., D<strong>ale</strong>, C.J.,<br />

Wesselingh, S.L. (2003), J. Neurovirol., 9(4):442<br />

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Zuckerman, E.E., Hardy, W.D. Jr. (2003),<br />

Onderstepoort J. Vet. Res., 70(1):1<br />

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Bolea, R., Vargas, M.A., Van Eynde, G., Saman, E.,<br />

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Res. Commun., 26(3):239<br />

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23.7. INFECłII PRODUSE DE SPUMAVIRUSURI<br />

Marina Spânu<br />

Spumavirinele, denumite astfel datorită<br />

caracterului dantelat al leziunii celulare pe care o<br />

determină in vitro, pot produce infecŃii la o<br />

varietate de specii de mamifere: primate nonumane,<br />

feline şi la bovine (16). Atât la gazdele<br />

lor natur<strong>ale</strong>, cât şi în cazul transmiterii<br />

accident<strong>ale</strong> la om, aceste virusuri determină<br />

infecŃii per<strong>si</strong>stente, aparent benigne. Asocierea<br />

spumavirusurilor descrise şi caracterizate, cu<br />

diferite boli evolutive clinic sau epidemiologia<br />

acestora, nu este certă.<br />

Spumavirusul uman (SVU). Retrovirusuri<br />

cauzând efecte microscopice <strong>si</strong>milare au fost<br />

izolate din câteva linii celulare cultur<strong>ale</strong> umane<br />

iar anticorpi faŃă de spumavirus pot fi detectaŃi în<br />

ser. În ciuda lipsei s<strong>ale</strong> aparente de patogenitate,<br />

există rapoarte referitoare la identificarea unor<br />

secvenŃe din genomul spumaviral la un pacient cu<br />

<strong>si</strong>ndrom hidropic Turner şi translocaŃie Y;16, la<br />

nivelul heterocromatinei (14). Presupusa<br />

implicarea a spumavirusului uman în etiologia<br />

<strong>si</strong>ndromului oboselii cronice (chronic fatigue<br />

syndrome) a fost infirmată prin utilizarea<br />

tehnicilor PCR şi Southern blot (6).<br />

Infectivitatea spumavirusului uman este<br />

strâns legată de reziduul aspartic (9) şi de<br />

existenŃa unei replicării celulare active, ca şi în<br />

cazul virusului leucemiei murine (2).<br />

Spumavirusul <strong>si</strong>nciŃial bovin (SVB).<br />

Evaluarea comparativă a diferenŃelor structur<strong>ale</strong><br />

dintre spumavirusurile bovin şi <strong>si</strong>mian a relevat<br />

deosebiri esenŃi<strong>ale</strong> între secvenŃa de aminoacizi,

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