Therapies for Children With Autism Spectrum Disorders

More documents

Recommendations

Info

moderate to large effect sizes). Growth in receptive language was not significantly affected by the intervention from pre-intervention to 12 months post-intervention. Children in the both the joint attention and symbolic play groups showed significantly more growth in initiation of joint attention and duration of child-initiated joint attention than did the control group (p
oom as the other assessments, so it is not clear whether the targeted social skills would generalize to more naturalistic settings with peers. In medical studies, although the treatment is prescribed in a clinical setting, it is generally administered at home, and one would expect effects of medications to be observed in terms of behavior in the home and other settings. However, medical studies may be good sources of information on the duration of perceived effects. Unfortunately, other than case series data for risperidone 177,203,204,206,213 demonstrating continued effects and side effects beyond six months. few data are available on longer term outcomes of medical treatment. Two of the case series studies of SRIs are based upon durations of treatment longer than 6 months, but the general and sometimes qualitative ratings of change in these studies are difficult to compare with the results of the RCTs to understand if medication responses reported in RCTs are likely to be durable. 221,224 KQ6. Drivers of Treatment Effects No studies were identified to answer this key question. KQ7. Treatment Approaches for Children Under Age Two at Risk for Diagnosis of ASDs This section presents the results of our literature search and findings regarding the use of treatment approaches in younger children who are at high risk of developing autism based upon behavioral, medical, or genetic risk factors. Studies located typically included participants whose mean age exceeded 24 months; however, the studies address interventions which can be used with children under age 2. The average age for diagnosis of ASDs in the US is not until at least age 3, but a reliable diagnosis may be possible as early as age 2. 291-293 Research suggesting that early intervention can improve outcomes has compelled investigators to consider intervening in very young children. 115 We identified four papers 178,290,294,295 with unique study populations addressing treatment approaches for very young children. Three studies were conducted in the US 178,290,294 and one in the UK. 295 Two of the studies were prospective case series, 178,294 one was a nonrandomized controlled trial, 295 and one was a randomized controlled trial. 290 Table 26 summarizes outcomes for studies considered to be fair or good quality and employing comparison groups. The RCT 290 and nonrandomized trial 295 were completed in a clinic setting with instruction to continue with parents at home. All children in the RCT met DSM-IV criteria as well as criteria on ADOS and Toddler Diagnostic Interview for diagnosis confirmation; the mean age of participants in the treatment and control groups was 23 months. The nonrandomized trial 295 employed parent training techniques to teach social communication skills and included children with a mean age of 38 months in the intervention group and 34 months in the control group. One of the case series describes an evaluation of techniques to train personnel to provide ESDM-based therapy and included children with a mean age of 33 months. 178 The second case series 294 was completed in the home and classroom and focused on social-communication and language outcomes; children assessed in the study were between 18 and 36 months. Among studies in this section, 1 was considered good quality, 1 fair quality, and 2 were considered poor. The Dawson et al. 290 randomized controlled trial evaluated the effectiveness of the ESDM for young children with ASDs. ESDM, a comprehensive, manualized intervention that blends ABA with developmental and relational approaches, was designed to be used with children as young as 12 months, delivered in the home, and to utilize parents as well as trained therapists. 95
Page 1 and 2:
Comparative Effectiveness Review Nu
Page 3 and 4:
This report is based on research co
Page 5 and 6:
Acknowledgments We are indebted to
Page 7 and 8:
Therapies for Children With Autism
Page 9 and 10:
Dietary and Other Medical Intervent
Page 11 and 12:
Figures Figure A. Analytic framewor
Page 13 and 14:
Table A. Description of interventio
Page 15 and 16:
Analytic Framework Figure A. Analyt
Page 17 and 18:
Strength of evidence. The degree of
Page 19 and 20:
epetitive behavior showed improveme
Page 21 and 22:
subgroups of children, although the
Page 23 and 24:
We encourage investigators to provi
Page 25 and 26:
9. Remington B, Hastings RP, Kovsho
Page 27 and 28:
46. Green J, Charman T, McConachie
Page 29 and 30:
82. Reaven JA, Blakeley-Smith A, Ni
Page 31 and 32:
120. Masi G, Cosenza A, Mucci M, et
Page 33 and 34:
157. Evangeliou A, Vlachonikolis I,
Page 35 and 36:
Introduction Need for Evidence for
Page 37 and 38:
Interventions intended primarily to
Page 39 and 40:
Table 1. Description of behavioral
Page 41 and 42:
Serotonin reuptake inhibitors. Sero
Page 43 and 44:
Table 3. Description of medical and
Page 45 and 46:
Table 4. Description of allied heal
Page 47 and 48:
Key Questions and Analytic Framewor
Page 49 and 50:
Chapter 4 discusses the results in
Page 51 and 52:
Methods This chapter documents proc
Page 53 and 54:
• Did not present aggregated resu
Page 55 and 56:
Additional behavioral interventions
Page 57 and 58:
1. Did the study employ a group des
Page 59 and 60:
Scoring: Studies minimally had to h
Page 61 and 62:
These ratings of applicability do n
Page 63 and 64:
Figure 2. Disposition of articles a
Page 65 and 66:
• ABA-based approaches including
Page 67 and 68:
education, children in the intensiv
Page 69 and 70:
abilities. This finding is further
Page 71 and 72:
Table 10. Outcomes of early intensi
Page 73 and 74:
forecast behavior; perspective taki
Page 75 and 76:
interaction with peers; outcome mea
Page 77 and 78: hyperactivity, inattention, challen
Page 79 and 80: Table 12. Outcomes of RCTs assessin
Page 81 and 82: Schedule for Affective Disorders an
Page 83 and 84: SCAS-P=Spence Child Anxiety Scale-P
Page 85 and 86: Summary of the literature. Jarusiew
Page 87 and 88: Table 14. Overview of educational s
Page 89 and 90: on the Ankara Developmental Screeni
Page 91 and 92: Checklist scores decreased by 8.4 f
Page 93 and 94: Table 15. Outcomes of studies asses
Page 95 and 96: evaluated the effects of risperidon
Page 97 and 98: that this somnolence improved over
Page 99 and 100: Table 17. Outcomes of RCTs of antip
Page 101 and 102: Serotonin Reuptake Inhibitors SRIs
Page 103 and 104: One prospective case series of esci
Page 105 and 106: Most participants were recruited fr
Page 107 and 108: Dietary and Other Medical Intervent
Page 109 and 110: Summary of the literature-other int
Page 111 and 112: withdrew after the first six weeks;
Page 113 and 114: therefore described separately belo
Page 115 and 116: addressed, 85 typically involves on
Page 117 and 118: In the second paper, 89 treatment s
Page 119 and 120: Table 25. Overview of CAM studies a
Page 121 and 122: Teacher and Parent Scales, behavior
Page 123 and 124: Because of the potentially increase
Page 125 and 126: Educational Interventions Child cha
Page 127: showed diminished response to escit
Page 131 and 132: contrast group (n=18) on three meas
Page 133 and 134: and are based on consideration of f
Page 135 and 136: Few studies directly comparing the
Page 137 and 138: Strength of evidence. The strength
Page 139 and 140: While individual studies of CBT and
Page 141 and 142: Table 32. Summary of results of edu
Page 143 and 144: Table 33. Summary of results of med
Page 145 and 146: strength of this reviewed literatur
Page 147 and 148: Table 36. Intervention, strength of
Page 149 and 150: Table 37. Interventions/outcomes wi
Page 151 and 152: gains. 104 Other studies have seen
Page 153 and 154: percent of behavioral studies repor
Page 155 and 156: limited followup, lack of comparati
Page 157 and 158: individual intervention is warrante
Page 159 and 160: selecting participants for their st
Page 161 and 162: studies lacked an arm that consider
Page 163 and 164: 23. Kanner L. Autistic Disturbances
Page 165 and 166: 62. Dosman CF, Drmic IE, Brian JA,
Page 167 and 168: 104. Ben-Itzchak E and Zachor DA. T
Page 169 and 170: 142. Tyminski RF and Moore PJ. The
Page 171 and 172: 177. Aman MG, McDougle CJ, Scahill
Page 173 and 174: 214. Correia CT, Almeida JP, Santos
Page 175 and 176: 252. Akhondzadeh S, Tajdar H, Moham
Page 177 and 178: 290. Dawson G, Rogers S, Munson J,
Page 179 and 180:
Acronyms/Abbreviations ABA Applied
Page 181 and 182:
Appendix A. Exact Search Strings an
Page 183 and 184:
Table A2. PsycINFO search strategie
Page 185 and 186:
Therapies for Children with Autism
Page 187 and 188:
Therapies for Children with ASD Sys
Page 189 and 190:
Appendix C. Evidence Tables Tables
Page 191 and 192:
Evidence Table. Therapies for child
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
Page 299 and 300:
Page 301 and 302:
Page 303 and 304:
Page 305 and 306:
Page 307 and 308:
Page 309 and 310:
Page 311 and 312:
Page 313 and 314:
Page 315 and 316:
Page 317 and 318:
Page 319 and 320:
Page 321 and 322:
Page 323 and 324:
Page 325 and 326:
Page 327 and 328:
Page 329 and 330:
Page 331 and 332:
Page 333 and 334:
Page 335 and 336:
Page 337 and 338:
Page 339 and 340:
Page 341 and 342:
Page 343 and 344:
Page 345 and 346:
Page 347 and 348:
Page 349 and 350:
Page 351 and 352:
Page 353 and 354:
Page 355 and 356:
Page 357 and 358:
Page 359 and 360:
Page 361 and 362:
Page 363 and 364:
Page 365 and 366:
Page 367 and 368:
Page 369 and 370:
Page 371 and 372:
Page 373 and 374:
Page 375 and 376:
Page 377 and 378:
Page 379 and 380:
Page 381 and 382:
Page 383 and 384:
Page 385 and 386:
Page 387 and 388:
Page 389 and 390:
Page 391 and 392:
Page 393 and 394:
Page 395 and 396:
Page 397 and 398:
Page 399 and 400:
Page 401 and 402:
Page 403 and 404:
Page 405 and 406:
Page 407 and 408:
Page 409 and 410:
Page 411 and 412:
Page 413 and 414:
Page 415 and 416:
Page 417 and 418:
Page 419 and 420:
Page 421 and 422:
Page 423 and 424:
Page 425 and 426:
Page 427 and 428:
Page 429 and 430:
Page 431 and 432:
Page 433 and 434:
Page 435 and 436:
Page 437 and 438:
Page 439 and 440:
Page 441 and 442:
Page 443 and 444:
Page 445 and 446:
Page 447 and 448:
Page 449 and 450:
Page 451 and 452:
Page 453 and 454:
Page 455 and 456:
Page 457 and 458:
Page 459 and 460:
Page 461 and 462:
Page 463 and 464:
Page 465 and 466:
Page 467 and 468:
Page 469 and 470:
Page 471 and 472:
Page 473 and 474:
Page 475 and 476:
Page 477 and 478:
Page 479 and 480:
Page 481 and 482:
Page 483 and 484:
Page 485 and 486:
Page 487 and 488:
Page 489 and 490:
Page 491 and 492:
Page 493 and 494:
Page 495 and 496:
Page 497 and 498:
Page 499 and 500:
Page 501 and 502:
Page 503 and 504:
Page 505 and 506:
Page 507 and 508:
Page 509 and 510:
Page 511 and 512:
Page 513 and 514:
Page 515 and 516:
Page 517 and 518:
Page 519 and 520:
Page 521 and 522:
Page 523 and 524:
Page 525 and 526:
Page 527 and 528:
Page 529 and 530:
Page 531 and 532:
Page 533 and 534:
Page 535 and 536:
Page 537 and 538:
Page 539 and 540:
Page 541 and 542:
Page 543 and 544:
Page 545 and 546:
Page 547 and 548:
Page 549 and 550:
Page 551 and 552:
Page 553 and 554:
Page 555 and 556:
Page 557 and 558:
Page 559 and 560:
Page 561 and 562:
Page 563 and 564:
Page 565 and 566:
Page 567 and 568:
Page 569 and 570:
Page 571 and 572:
Page 573 and 574:
Page 575 and 576:
Page 577 and 578:
Page 579 and 580:
Page 581 and 582:
Page 583 and 584:
Page 585 and 586:
Page 587 and 588:
Page 589 and 590:
Page 591 and 592:
Page 593 and 594:
Page 595 and 596:
Page 597 and 598:
Country: US Practice setting: Clini
Page 599 and 600:
Dunn-Geier et al., 2000 (continued)
Page 601 and 602:
Evidence Table: Therapies for Child
Page 603 and 604:
Page 605 and 606:
Page 607 and 608:
Appendix D. List of Excluded Studie
Page 609 and 610:
31. Aarsland D, Cummings JL and Lar
Page 611 and 612:
59. Ahearn WH, Clark KM, Gardenier
Page 613 and 614:
89. Allison DB, Basile VC and MacDo
Page 615 and 616:
118. Ando H, Yoshimura I and Wakaba
Page 617 and 618:
146. Atkinson RP, Jenson WR, Rovner
Page 619 and 620:
177. Bakare MO, Agomoh AO, Ebigbo P
Page 621 and 622:
204. Baron-Cohen S, Scott FJ, Allis
Page 623 and 624:
233. Bebko JM, Perry A and Bryson S
Page 625 and 626:
262. Bergmann F, Stepp H, Metzger R
Page 627 and 628:
291. Birkan B, McClannahan LE and K
Page 629 and 630:
319. Boddy F, Rowan EN, Lett D, et
Page 631 and 632:
348. Bouma R and Schweitzer R. The
Page 633 and 634:
376. Broadstock M, Doughty C and Eg
Page 635 and 636:
404. Brudnak MA. Application of gen
Page 637 and 638:
432. Buitelaar JK. Why have drug tr
Page 639 and 640:
460. Butler DE, Nordin IC, L’Ital
Page 641 and 642:
489. Campbell M, Locascio JJ, Choro
Page 643 and 644:
517. Caronna EB, Augustyn M and Zuc
Page 645 and 646:
546. Case-Smith J and Miller H. Occ
Page 647 and 648:
574. Charlop MH, Burgio LD, Iwata B
Page 649 and 650:
602. Cheng CW, Cho SH, Taylor M, et
Page 651 and 652:
631. Cicero FR and Pfadt A. Investi
Page 653 and 654:
662. Collier D and Reid G. A compar
Page 655 and 656:
691. Coskun M, Karakoc S, Kircelli
Page 657 and 658:
718. Cullen LA, Barlow JH and Cushw
Page 659 and 660:
748. Davidovitch M, Holtzman G and
Page 661 and 662:
777. DeLeon IG, Fisher WW and Marhe
Page 663 and 664:
805. Devlin SD, Harber MM. Collabor
Page 665 and 666:
834. Doherty K, Fitzgerald M and Ma
Page 667 and 668:
863. Dudley LL, Johnson C and Barne
Page 669 and 670:
893. Dybvik AC. Autism and the Incl
Page 671 and 672:
924. Elder JH. In-home communicatio
Page 673 and 674:
953. Erickson CA, Posey DJ, Stigler
Page 675 and 676:
979. Faja S, Aylward E, Bernier R,
Page 677 and 678:
1008. Ferri R, Elia M, Agarwal N, e
Page 679 and 680:
1037. Fisher W, Kerbeshian J and Bu
Page 681 and 682:
1066. Fragala-Pinkham M, Haley SM a
Page 683 and 684:
1095. Furneaux B. Keeping the balan
Page 685 and 686:
1124. Garcaa-Villamisar D, Wehman P
Page 687 and 688:
1152. Ghezzi PM. Discrete Trials Te
Page 689 and 690:
1180. Goin-Kochel RP, Myers BJ and
Page 691 and 692:
1210. Gordon R, Handleman JS and Ha
Page 693 and 694:
1239. Grimaldi BL. The central role
Page 695 and 696:
1268. Guptill JT, Booker AB, Gibbs
Page 697 and 698:
1296. Hamdan-Allen G. Brief report:
Page 699 and 700:
1324. Hare DJ, Jones JPR and Paine
Page 701 and 702:
1356. Harrison S and Berry L. Valui
Page 703 and 704:
1386. Heilbrun AB, Jr., Blum N and
Page 705 and 706:
1414. Hetzroni OE and Shalem U. Fro
Page 707 and 708:
1443. Holburn CS. Counter the mistr
Page 709 and 710:
1473. Horner RH, Carr EG, Strain PS
Page 711 and 712:
1504. Hughes C, Soares-Boucaud I, H
Page 713 and 714:
1533. Ijichi S and Ijichi N. Beyond
Page 715 and 716:
1562. James SJ, Cutler P, Melnyk S,
Page 717 and 718:
1591. Johnson CR, Butter EM, Handen
Page 719 and 720:
1619. Joyce PR. The medical model-w
Page 721 and 722:
1647. Karmali I, Greer RD, Nuzzolo-
Page 723 and 724:
1673. Kelly AB, Garnett MS, Attwood
Page 725 and 726:
1702. Kielinen M, Linna SL and Moil
Page 727 and 728:
1731. Klin A, Lin DJ, Gorrindo P, e
Page 729 and 730:
1761. Koegel RL and Frea WD. Treatm
Page 731 and 732:
1790. Kolmen BK, Feldman HM, Handen
Page 733 and 734:
1819. Kratochvil CJ, Findling RL, M
Page 735 and 736:
1846. Lam MK and Rao N. Developing
Page 737 and 738:
1874. Lattimore LP, Parsons MB and
Page 739 and 740:
1903. Lee PC. Verification of a sim
Page 741 and 742:
1932. Lerman DC, Vorndran C, Addiso
Page 743 and 744:
1960. Licciardello CC, Harchik AE a
Page 745 and 746:
1989. Liptak GS, Orlando M, Yinglin
Page 747 and 748:
2015. Lorimer PA, Simpson RL, Myles
Page 749 and 750:
2043. Luiselli JK, Kane A, Treml T,
Page 751 and 752:
2071. MacFarlane JR and Kanaya T. W
Page 753 and 754:
2099. Malone RP, Maislin G, Choudhu
Page 755 and 756:
2127. Marin FZ. CAM versus nucleopl
Page 757 and 758:
2157. Martineau J, Roux S, Adrien J
Page 759 and 760:
2185. Matson JL and Lo Vullo SV. A
Page 761 and 762:
2213. McCabe H. The Importance of P
Page 763 and 764:
2240. McDougle CJ, Holmes JP, Carls
Page 765 and 766:
2267. McHale SM, Olley JG, Marcus L
Page 767 and 768:
2296. Merlo LJ, Lehmkuhl HD, Geffke
Page 769 and 770:
2325. Minderaa RB, Anderson GM, Vol
Page 771 and 772:
2354. Montgomery JM, Duncan CR and
Page 773 and 774:
2385. Morrison RS, Sainato DM, Benc
Page 775 and 776:
2413. Munesue T, Ono Y, Mutoh K, et
Page 777 and 778:
2445. Napolitano DA, Tessing JL, Mc
Page 779 and 780:
2474. Niederhofer H and Pittschiele
Page 781 and 782:
2501. Nwora AJ and Gee BM. A case s
Page 783 and 784:
2530. Olive ML, Lang RB and Davis T
Page 785 and 786:
2559. Owens JA, Rosen CL and Mindel
Page 787 and 788:
2589. Pansegrouw I and Alant E. Com
Page 789 and 790:
2618. Paul C, Williams KE, Riegel K
Page 791 and 792:
2646. Perry R, Nobler MS and Campbe
Page 793 and 794:
2675. Piazza CC, Hagopian LP, Hughe
Page 795 and 796:
2704. Poon L, Partika N and Bolman
Page 797 and 798:
2734. Prizant BM. Speech-language p
Page 799 and 800:
2764. Rapp JT, Vollmer TR, St. Pete
Page 801 and 802:
2792. Reed P, Broomfield L, McHugh
Page 803 and 804:
2819. Remington G, Sloman L, Konsta
Page 805 and 806:
2849. Ringdahl JE, Kitsukawa K, And
Page 807 and 808:
2877. Rogers SJ. Interventions that
Page 809 and 810:
2908. Rossignol DA. Novel and emerg
Page 811 and 812:
2939. Rutter M, Kreppner J, Croft C
Page 813 and 814:
2967. Sandt D. Social Stories for S
Page 815 and 816:
2994. Scanlon K. Art therapy with a
Page 817 and 818:
3023. Schneider CK, Melmed RD, Bars
Page 819 and 820:
3054. Schwartz IS, Sandall SR, Garf
Page 821 and 822:
3085. Shafer MS, Egel AL and Neef N
Page 823 and 824:
3115. Shipley-Benamou R, Lutzker JR
Page 825 and 826:
3143. Siller M and Sigman M. The be
Page 827 and 828:
3173. Smith C, Felce D, Jones E, et
Page 829 and 830:
3202. Snyder A, Bossomaier T and Mi
Page 831 and 832:
3230. Spero MH. The emancipation of
Page 833 and 834:
3259. Stephens CE. Spontaneous imit
Page 835 and 836:
3289. Strambi M, Longini M, Hayek J
Page 837 and 838:
3318. Suzumura K. How an autistic b
Page 839 and 840:
3346. Tager-Flusberg H and Calkins
Page 841 and 842:
3376. Taylor I, O’Reilly M and La
Page 843 and 844:
3407. Thunberg G, Ahlsen E and Sand
Page 845 and 846:
3435. Trembath D, Balandin S, Toghe
Page 847 and 848:
3464. Turner-Brown LM, Perry TD, Di
Page 849 and 850:
3492. Van Der Putt R, Dineen C, Jan
Page 851 and 852:
3522. Vitiello B. Recent NIMH clini
Page 853 and 854:
3553. Walenski M, Mostofsky SH, Gid
Page 855 and 856:
3581. Weber RC and Thorpe J. Teachi
Page 857 and 858:
3610. Wheeler JJ, Baggett BA, Fox J
Page 859 and 860:
3637. Williams B. Mental handicap n
Page 861 and 862:
3669. Wimpory D, Chadwick P and Nas
Page 863 and 864:
3698. Worth S and Reynolds S. The A
Page 865 and 866:
3728. Young JM, Krantz PJ, McClanna
Page 867 and 868:
3759. Zuddas A, Di Martino A, Mugli
Page 869 and 870:
Appendix F. Approach to Categorizin
Page 871 and 872:
APPENDIX G. Discussion of Recent Sy
Page 873 and 874:
one a casein free regime. Diets wer
Page 875 and 876:
outcome data as Type 6, defined as
Page 877 and 878:
Yes—no disclosures to make G7 Bai
Page 879 and 880:
Table G1. Characteristics of recent
Page 881 and 882:
Random assignment Appropriate compa
Page 883 and 884:
Page 885 and 886:
Page 887 and 888:
Page 889 and 890:
Page 891 and 892:
Page 893 and 894:
Study Group design Random assignmen
Page 895 and 896:
Page 897 and 898:
Page 899 and 900:
Page 901 and 902:
Page 903 and 904:
Page 905 and 906:
APPENDIX I. Applicability Summary T
Page 907 and 908:
Social skills (continued) Domain De
show all

Therapies for Children With Autism Spectrum Disorders

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?