Therapies for Children With Autism Spectrum Disorders

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2227. McConnell SR. Interventions to facilitate social interaction for young children with autism: review of available research and recommendations for educational intervention and future research. J Autism Dev Disord. 2002 Oct;32(5):351-72. X-1, X-2, X-3, X-4 2228. McCormick MC. The autism “epidemic”: impressions from the perspective of immunization safety review. Ambul Pediatr. 2003 May-Jun;3(3):119-20. X-1, X-2, X-3, X-4 2229. McCrory E, Henry LA and Happe F. Eye-witness memory and suggestibility in children with Asperger syndrome. J Child Psychol Psychiatry. 2007 May;48(5):482-9. X-4 2230. McDaniel KD. Pharmacologic treatment of psychiatric and neurodevelopmental disorders in children and adolescents (Part 2). Clin Pediatr (Phila). 1986 Mar;25(3):143-6. X-1, X- 2, X-3, X-4, X-10 2231. McDermott S, Moran R, Platt T, et al. Prevalence of Epilepsy in Adults With Mental Retardation and Related Disabilities in Primary Care. American Journal on Mental Retardation. 2005 Jan;110(1):48-56. X-1, X-4 2232. McDermott S, Zhou L and Mann J. Injury treatment among children with autism or pervasive developmental disorder. J Autism Dev Disord. 2008 Apr;38(4):626-33. X-4 2233. McDonald ME and Hemmes NS. Increases in Social Initiation toward an Adolescent with Autism: Reciprocity Effects. Research in Developmental Disabilities Journal Citation: v24 n6 p453-65 Nov-Dec 2003 Publisher:. 2003 Pub Types: Journal Articles; Reports - Research. X-1, X-3, X-4 2234. McDonnell A, Sturmey P, Oliver C, et al. The Effects of Staff Training on Staff Confidence and Challenging Behavior in Services for People with Autism Spectrum Disorders. Research in Autism Spectrum Disorders. 2008 Apr-Jun;2(2):311-319. X-1, X- 3, X-4 2235. McDonnell J, Thorson N, McQuivey C, et al. Academic engaged time of students with low-incidence disabilities in general education classes. Ment Retard. 1997 Feb;35(1):18- 26. X-3, X-4, X-10 2236. McDonnell MA, Hamrin V, Moffett J, et al. Timely diagnosis of comorbid pervasive developmental disorder and bipolar disorder. Minerva Pediatr. 2008 Feb;60(1):115-27. X-1, X-2, X-4 2237. McDougle CJ, Brodkin ES, Naylor ST, et al. Sertraline in adults with pervasive developmental disorders: a prospective open-label investigation. J Clin Psychopharmacol. 1998 Feb;18(1):62-6. X-1, X-3, X-10 2238. McDougle CJ, Brodkin ES, Yeung PP, et al. Risperidone in adults with autism or pervasive developmental disorder. Journal of Child and Adolescent Psychopharmacology. 1995 Win;5(4):273-282. X-1, X-3, X-10 2239. McDougle CJ, Holmes JP, Bronson MR, et al. Risperidone treatment of children and adolescents with pervasive developmental disorders: a prospective open-label study. J Am Acad Child Adolesc Psychiatry. 1997 May;36(5):685-93. X-10 D-156
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Comparative Effectiveness Review Nu
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This report is based on research co
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Acknowledgments We are indebted to
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Therapies for Children With Autism
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Dietary and Other Medical Intervent
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Figures Figure A. Analytic framewor
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Table A. Description of interventio
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Analytic Framework Figure A. Analyt
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Strength of evidence. The degree of
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epetitive behavior showed improveme
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subgroups of children, although the
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We encourage investigators to provi
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9. Remington B, Hastings RP, Kovsho
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46. Green J, Charman T, McConachie
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82. Reaven JA, Blakeley-Smith A, Ni
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120. Masi G, Cosenza A, Mucci M, et
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157. Evangeliou A, Vlachonikolis I,
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Introduction Need for Evidence for
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Interventions intended primarily to
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Table 1. Description of behavioral
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Serotonin reuptake inhibitors. Sero
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Table 3. Description of medical and
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Table 4. Description of allied heal
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Key Questions and Analytic Framewor
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Chapter 4 discusses the results in
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Methods This chapter documents proc
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• Did not present aggregated resu
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Additional behavioral interventions
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1. Did the study employ a group des
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Scoring: Studies minimally had to h
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These ratings of applicability do n
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Figure 2. Disposition of articles a
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• ABA-based approaches including
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education, children in the intensiv
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abilities. This finding is further
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Table 10. Outcomes of early intensi
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forecast behavior; perspective taki
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interaction with peers; outcome mea
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hyperactivity, inattention, challen
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Table 12. Outcomes of RCTs assessin
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Schedule for Affective Disorders an
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SCAS-P=Spence Child Anxiety Scale-P
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Summary of the literature. Jarusiew
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Table 14. Overview of educational s
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on the Ankara Developmental Screeni
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Checklist scores decreased by 8.4 f
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Table 15. Outcomes of studies asses
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evaluated the effects of risperidon
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that this somnolence improved over
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Table 17. Outcomes of RCTs of antip
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Serotonin Reuptake Inhibitors SRIs
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One prospective case series of esci
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Most participants were recruited fr
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Dietary and Other Medical Intervent
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Summary of the literature-other int
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withdrew after the first six weeks;
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therefore described separately belo
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addressed, 85 typically involves on
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In the second paper, 89 treatment s
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Table 25. Overview of CAM studies a
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Teacher and Parent Scales, behavior
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Because of the potentially increase
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Educational Interventions Child cha
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showed diminished response to escit
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oom as the other assessments, so it
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contrast group (n=18) on three meas
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and are based on consideration of f
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Few studies directly comparing the
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Strength of evidence. The strength
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While individual studies of CBT and
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Table 32. Summary of results of edu
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Table 33. Summary of results of med
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strength of this reviewed literatur
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Table 36. Intervention, strength of
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Table 37. Interventions/outcomes wi
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gains. 104 Other studies have seen
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percent of behavioral studies repor
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limited followup, lack of comparati
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individual intervention is warrante
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selecting participants for their st
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studies lacked an arm that consider
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23. Kanner L. Autistic Disturbances
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62. Dosman CF, Drmic IE, Brian JA,
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104. Ben-Itzchak E and Zachor DA. T
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142. Tyminski RF and Moore PJ. The
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177. Aman MG, McDougle CJ, Scahill
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214. Correia CT, Almeida JP, Santos
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252. Akhondzadeh S, Tajdar H, Moham
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290. Dawson G, Rogers S, Munson J,
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Acronyms/Abbreviations ABA Applied
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Appendix A. Exact Search Strings an
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Table A2. PsycINFO search strategie
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Therapies for Children with Autism
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Therapies for Children with ASD Sys
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Appendix C. Evidence Tables Tables
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Evidence Table. Therapies for child
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Country: US Practice setting: Clini
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Dunn-Geier et al., 2000 (continued)
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Evidence Table: Therapies for Child
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Appendix D. List of Excluded Studie
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31. Aarsland D, Cummings JL and Lar
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59. Ahearn WH, Clark KM, Gardenier
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89. Allison DB, Basile VC and MacDo
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118. Ando H, Yoshimura I and Wakaba
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146. Atkinson RP, Jenson WR, Rovner
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177. Bakare MO, Agomoh AO, Ebigbo P
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204. Baron-Cohen S, Scott FJ, Allis
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233. Bebko JM, Perry A and Bryson S
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262. Bergmann F, Stepp H, Metzger R
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291. Birkan B, McClannahan LE and K
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319. Boddy F, Rowan EN, Lett D, et
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348. Bouma R and Schweitzer R. The
Page 633 and 634:
376. Broadstock M, Doughty C and Eg
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404. Brudnak MA. Application of gen
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432. Buitelaar JK. Why have drug tr
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460. Butler DE, Nordin IC, L’Ital
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489. Campbell M, Locascio JJ, Choro
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517. Caronna EB, Augustyn M and Zuc
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546. Case-Smith J and Miller H. Occ
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574. Charlop MH, Burgio LD, Iwata B
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602. Cheng CW, Cho SH, Taylor M, et
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631. Cicero FR and Pfadt A. Investi
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662. Collier D and Reid G. A compar
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691. Coskun M, Karakoc S, Kircelli
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718. Cullen LA, Barlow JH and Cushw
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748. Davidovitch M, Holtzman G and
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777. DeLeon IG, Fisher WW and Marhe
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805. Devlin SD, Harber MM. Collabor
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834. Doherty K, Fitzgerald M and Ma
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863. Dudley LL, Johnson C and Barne
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893. Dybvik AC. Autism and the Incl
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924. Elder JH. In-home communicatio
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953. Erickson CA, Posey DJ, Stigler
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979. Faja S, Aylward E, Bernier R,
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1008. Ferri R, Elia M, Agarwal N, e
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1037. Fisher W, Kerbeshian J and Bu
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1066. Fragala-Pinkham M, Haley SM a
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1095. Furneaux B. Keeping the balan
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1124. Garcaa-Villamisar D, Wehman P
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1152. Ghezzi PM. Discrete Trials Te
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1180. Goin-Kochel RP, Myers BJ and
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1210. Gordon R, Handleman JS and Ha
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1239. Grimaldi BL. The central role
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1268. Guptill JT, Booker AB, Gibbs
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1296. Hamdan-Allen G. Brief report:
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1324. Hare DJ, Jones JPR and Paine
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1356. Harrison S and Berry L. Valui
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1386. Heilbrun AB, Jr., Blum N and
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1414. Hetzroni OE and Shalem U. Fro
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1443. Holburn CS. Counter the mistr
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1473. Horner RH, Carr EG, Strain PS
Page 711 and 712: 1504. Hughes C, Soares-Boucaud I, H
Page 713 and 714: 1533. Ijichi S and Ijichi N. Beyond
Page 715 and 716: 1562. James SJ, Cutler P, Melnyk S,
Page 717 and 718: 1591. Johnson CR, Butter EM, Handen
Page 719 and 720: 1619. Joyce PR. The medical model-w
Page 721 and 722: 1647. Karmali I, Greer RD, Nuzzolo-
Page 723 and 724: 1673. Kelly AB, Garnett MS, Attwood
Page 725 and 726: 1702. Kielinen M, Linna SL and Moil
Page 727 and 728: 1731. Klin A, Lin DJ, Gorrindo P, e
Page 729 and 730: 1761. Koegel RL and Frea WD. Treatm
Page 731 and 732: 1790. Kolmen BK, Feldman HM, Handen
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Page 739 and 740: 1903. Lee PC. Verification of a sim
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Page 751 and 752: 2071. MacFarlane JR and Kanaya T. W
Page 753 and 754: 2099. Malone RP, Maislin G, Choudhu
Page 755 and 756: 2127. Marin FZ. CAM versus nucleopl
Page 757 and 758: 2157. Martineau J, Roux S, Adrien J
Page 759 and 760: 2185. Matson JL and Lo Vullo SV. A
Page 761: 2213. McCabe H. The Importance of P
Page 765 and 766: 2267. McHale SM, Olley JG, Marcus L
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Page 769 and 770: 2325. Minderaa RB, Anderson GM, Vol
Page 771 and 772: 2354. Montgomery JM, Duncan CR and
Page 773 and 774: 2385. Morrison RS, Sainato DM, Benc
Page 775 and 776: 2413. Munesue T, Ono Y, Mutoh K, et
Page 777 and 778: 2445. Napolitano DA, Tessing JL, Mc
Page 779 and 780: 2474. Niederhofer H and Pittschiele
Page 781 and 782: 2501. Nwora AJ and Gee BM. A case s
Page 783 and 784: 2530. Olive ML, Lang RB and Davis T
Page 785 and 786: 2559. Owens JA, Rosen CL and Mindel
Page 787 and 788: 2589. Pansegrouw I and Alant E. Com
Page 789 and 790: 2618. Paul C, Williams KE, Riegel K
Page 791 and 792: 2646. Perry R, Nobler MS and Campbe
Page 793 and 794: 2675. Piazza CC, Hagopian LP, Hughe
Page 795 and 796: 2704. Poon L, Partika N and Bolman
Page 797 and 798: 2734. Prizant BM. Speech-language p
Page 799 and 800: 2764. Rapp JT, Vollmer TR, St. Pete
Page 801 and 802: 2792. Reed P, Broomfield L, McHugh
Page 803 and 804: 2819. Remington G, Sloman L, Konsta
Page 805 and 806: 2849. Ringdahl JE, Kitsukawa K, And
Page 807 and 808: 2877. Rogers SJ. Interventions that
Page 809 and 810: 2908. Rossignol DA. Novel and emerg
Page 811 and 812: 2939. Rutter M, Kreppner J, Croft C
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2967. Sandt D. Social Stories for S
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2994. Scanlon K. Art therapy with a
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3023. Schneider CK, Melmed RD, Bars
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3054. Schwartz IS, Sandall SR, Garf
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3085. Shafer MS, Egel AL and Neef N
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3115. Shipley-Benamou R, Lutzker JR
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3143. Siller M and Sigman M. The be
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3173. Smith C, Felce D, Jones E, et
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3202. Snyder A, Bossomaier T and Mi
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3230. Spero MH. The emancipation of
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3259. Stephens CE. Spontaneous imit
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3289. Strambi M, Longini M, Hayek J
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3318. Suzumura K. How an autistic b
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3346. Tager-Flusberg H and Calkins
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3376. Taylor I, O’Reilly M and La
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3407. Thunberg G, Ahlsen E and Sand
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3435. Trembath D, Balandin S, Toghe
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3464. Turner-Brown LM, Perry TD, Di
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3492. Van Der Putt R, Dineen C, Jan
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3522. Vitiello B. Recent NIMH clini
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3553. Walenski M, Mostofsky SH, Gid
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3581. Weber RC and Thorpe J. Teachi
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3610. Wheeler JJ, Baggett BA, Fox J
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3637. Williams B. Mental handicap n
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3669. Wimpory D, Chadwick P and Nas
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3698. Worth S and Reynolds S. The A
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3728. Young JM, Krantz PJ, McClanna
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3759. Zuddas A, Di Martino A, Mugli
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Appendix F. Approach to Categorizin
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APPENDIX G. Discussion of Recent Sy
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one a casein free regime. Diets wer
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outcome data as Type 6, defined as
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Yes—no disclosures to make G7 Bai
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Table G1. Characteristics of recent
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Random assignment Appropriate compa
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Study Group design Random assignmen
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APPENDIX I. Applicability Summary T
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Social skills (continued) Domain De
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Therapies for Children With Autism Spectrum Disorders

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