Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Author: Intervention:
Inclusion criteria: Overall ratings: Problem
Solomon et al., Parent Child Interaction • Met DSM-IV-TR criteria ADOS score, mean behavior:
2008
Therapy
for autistic disorder, ± SD (range): ECBI intensity
Country: Phase 1: Child directed aspergers disorder, or G1: 13.1 ± 4.3 score, mean ±
US
interaction, initially PDD-NOS
(8-22)
SD:
Practice clinician led, then parents • Met cutoffs for ASD on G2: 11.3 ± 3.6 G1: 59.70 ± 4.95
setting: coached until reached ADOS
(7-19)
G2: 62.22 ± 9.77
Academic mastery criteria (occurred • Met cutoffs for autism Problem behavior: G1/BL: P = NS
Intervention within 8 sessions for all on ADI-R
ECBI intensity G2/BL: P = NS
setting: participants)
• Clinically significant score, mean ± SD: G1/G2: P = 0.462
Clinic
Phase 2: Parent directed externalizing behavior G1: 67.0 ± 5.64 ECBI problem
Enrollment interaction, all parents problems on BASC G2: 65.67 ± 8.80 score, mean ±
period:
completed within 6 externalizing behavior ECBI problem SD:
NR
sessions.
scale OR exceed score, mean ± SD: G1: 52.00 ± 6.52
Funding: Mean length of total threshold on ECBI G1: 62.90 ± 6.30 G2: 63.00 ± 7.31
Children’s Miracle treatment: 12.7 sessions intensity scale
G2: 66.78 ± 8.51 G1/BL: P = 0.015
Network (one family relocated in Exclusion criteria: BASC externalizing G2/BL: P = NS
Author industry middle of CDI)
• FSIQ < 70 on WASI score, mean ± SD: G1/G2: P = 0.007
relationship Assessments:
• Not enough receptive or
G1: 71.1 ± 8.2 BASC aggression
disclosures: Parent rated ECBI, BASC,
expressive language
G2: 76.6 ± 14.9 score, mean ±
NR
PSI-SF; DPICS affect
abilities to participate in
BASC aggression SD:
Design: coding done in free play
language intensive
score, mean ± SD: G1: 59.00 ± 6.25
RCT
session (G1 only)
intervention
G1: 63.90 ± 10.58 G2: 67.78 ± 14.60
Groups:
Age, mean/yrs (range):
G2: 70.33 ± 14.21 G1/BL: P = NS
G1: intervention
G1: 8.2 ± 1.7 (6.0-10.8) BASC hyperactivity G2/BL: P = NS
G2: control (waiting list)
G2: 8.1 ± 2.2 (5.3-12.1) score, mean ± SD: G1/G2: P = 0.516
Provider:
Mental age:
G1: 74.30 ± 8.29 BASC
Five therapists (3 trained
WASI FSIQ, mean ± SD:
G2: 80.56 ± 13.95 hyperactivity
in PCIT with master G1: 100.11 ± 19.2 (83-135) BASC attention score, mean ±
trainers: shadowing and G2: 93.4 ± 16.8 (79-125) score, mean ± SD: SD:
practicing at least 6 mos; WASI VIQ, mean ± SD:
G1: 72.80 ±6.13 G1: 68.70 ± 11.68
2 trained in team working G1: 97.7 ± 18.4 (73-138)
G2: 70.89 ± 10.46 G2: 80.56 ± 8.31
with trained therapists) G2: 90.4 ± 20.3 (75-133) BASC conduct G1/BL: P = NS
Measure of treatment
WASI PIQ, mean ± SD:
score, mean ± SD: G2/BL: P = NS
fidelity reported: G1: 102.2 ± 21.6 (82-138)
G1: 67.40 ± 8.63 G1/G2: P = 0.055
Regular team coding G2: 94.7 ± 9.3 (84-110)
G2: 67.00 ± 14.03 BASC attention
meetings during study, Gender, n (%):
Social skills: score, mean ±
but no formal treatment
Male: 19 (100)
BASC adaptability SD:
fidelity measure taken Female: 0
score, mean ± SD: G1: 65.80 ±8.77
Co-interventions held Race/ethnicity:
G1: 23.90 ± 7.91 G2: 70.67 ± 10.92
stable during treatment:
NR
G2: 28.44 ± 6.48 G1/BL: P = NS
NR
SES:
BASC social skills G2/BL: P = NS
Concomitant therapies:
Maternal education: NR
score, mean ± SD: G1/G2: P = 0.062
NR
Household income: NR
G1: 30.20 ± 3.77 BASC conduct
N at enrollment: Diagnostic approach:
G2: 35.00 ± 10.52 score, mean ±
G1: 10
Referral, with diagnosis
BASC leadership SD:
G2: 9
Diagnostic tool/method: score, mean ± SD: G1: 59.90 ± 8.01
N at follow-up:
ADOS and ADI-R in study
G1: 36.20 ± 4.02 G2: 66.00 ± 10.44
G1: 10
DSM-IV-TR
G2: 33.89 ± 6.07 G1/BL: P = NS
G2: 9
G2/BL: P = NS
G1/G2: P = 0.059
Solomon et al.,
Diagnostic category: BASC depression Social skills:
2008 (continued)
Autism:
score, mean ± SD: BASC adaptability
G1: 4
G1: 60.00 ± 9.57 score, mean ±
G2: 4
G2: 72.33 ±15.68 SD:
PDD-NOS:
BASC atypicality G1: 32.40 ± 10.23
G1 : 0
score, mean ± SD: G2: 27.33 ± 10.38
C-175