Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion
Description Intervention
Criteria/Population
Henry et al., 2006 N at enrollment: Indications, n:
(continued) G1: 89
Anxiety: 61
N at follow-up:
Perseverations: 59
G1: 89
Aggression: 31
Depressed mood: 5
Family history, n:
PDDs: 18
Bipolar disorder: 12
Depression: 36
Mood disorder NOS: 2
Obsessive-compulsive
Disorder: 10
Panic disorder: 5
Anxiety NOS: 14
Posttraumatic stress
disorder: 1
Phobia: 1
Tic disorder: 2
Schizophrenia: 6
Psychosis NOS: 2
Mental retardation: 3
Learning disabililty: 7
Attention-deficit/
hyperactivity disorder: 18
Substance abuse: 12
Henry et al., 2006
(continued)
C-277
Baseline
Measures Outcomes
Bipolar disorder:
33 (P = 0.364)
Depression: 44
(P = 0.874)
Mood disorder
NOS: 0
(P = 0.192)
Obsessivecompulsive
disorder: 30
(P = 0.297)
Panic disorder: 60
(P = 0.501)
Anxiety NOS: 43
(P = 0.831)
PSD: 0
(P = 0.359)
Phobia: 100
(P = 0.271)
Tic disorder: 100
(P = 0.117)
Schizophrenia: 67
(P = 0.28)
Psychosis NOS:
100 (P = 0.117)
Mental
retardation: 100
(P = 0.108)
Learning
disabililty: 57
(P = 0.517)
Attention-deficit/
hyperactivity
disorder: 44
(P = 0.923)
Substance abuse:
25 (P = 0.126)
Harms:
Activation side
effects, n (%):
Total: 48 (53.9)
Agitation: 31
(34.8)
Aggression: 9
(10.1)
Increased
impulsivity: 9
(10.1)
Increased
distractibility: 6
(6.7)
Increased
hyperactivity: 9
(10.1)
Insomnia: 11
(12.4)
Euphoria: 1 (1.1)