Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion
Description Intervention
Criteria/Population
Author:
Intervention: Parent- Inclusion criteria:
Drew et al., training components Failure of all 6 items of
2002
included behavior Shortened version of the
Country: management strategies, CHAT
UK
development of social and ICD-10 criteria for
communicative
childhood autism
Practice competence, play skills, Exclusion criteria:
setting:
holistic learning, and General developmental
Academic integration into the delay
routine.
Age, mean/months ± SD:
Local services group G1: 21.4 ± 2.7
included speech and G2: 23.6 ± 3.8
language therapy, portage Mental age:
home worker input and NR
other paramedical therapy Gender, n (%):
services (OT), ABA: G1:
Lovaas
M: 11(91.7)
Follow up conducted 12 F: 1 (8.3)
months later (mean G2:
age=35 months) M: 8 (66.7)
F: 4 (33.3)
Intervention
setting: Hospital
clinic
Enrollment
period: NR
Funding:
Agency:
Medical research
council
Project grant &
from the Special
Trustees of Guy’s
Hospital
Author industry
relationship
disclosures:
NR
Design: RCT
Assessments:
Research team
administered at baseline
and follow-up: MCDI,
Griffiths Scale of Infant
Development, & ADI-R
Groups:
G1: Parent training
G2: Local services
Frequency of contact:
Hrs/week, mean ± SD:
G1: 6.3 ± 10.7
G2: 3.5 ± 3.6
Provider:
Research team
Measure of treatment
fidelity reported:
No
Co-interventions held
stable during treatment:
NR
Concomitant therapies,
n (%):
G2: 3 in intensive homebased
behavioral program
Hrs/week of Other
interventions:
G1: 0.3 ± 0.1
G2: 8.4 ± 14.9
F(1,23) = 3.6, P = 0.07
Race/ethnicity:
NR
SES:
Maternal education: NR
Household income: NR
Diagnostic approach:
In study
Diagnostic tool/method:
CHAT –for screening
ADI-R & structures childadult
interaction
assessment
ICD-10
Structured clinical interview
Diagnostic category, n
(%):
Autism/PDD-NOS: 24
(100)
Other characteristics:
Hrs/wk spent in playgroup /
nursery, mean ± SD:
G1: 6.3 ± 10.7
G2: 3.5 ± 3.6
P = NS
C-375
Baseline
Measures Outcomes
Educational/ Educational/
cognitive/ cognitive/
academic academic
attainment: attainment:
Non-Verbal IQ, Non-Verbal IQ,
mean ± SD: mean ± SD:
G1: 88.1 ± 11.2 G1: 77.9 ± 14.8
G2: 66.0 ± 16.5 G2: 66.1 ± 17.1
P = NS
NVIQ significantly
different between
G1 & G2 (P < 0.001)
Communication/
language:
Words understood,
mean ± SD:
G1: 52 ± 60.5
G2: 53.0 ± 63.7
Words said, mean ±
SD:
G1: 6.8 ± 20.9
G2: 6.6 ± 13.7
Total gestures
produced, mean ±
SD:
G1: 20.9 ± 7.0
G2: 20.9 ± 14.4
ADI-Non-Verbal
Communication,
mean ± SD:
G1: 12.8 ± 1.6
G2: 12 ± 2.4
ADI overall
language rating, n:
G1:
Nonverbal (< 5
words): 11
Single words: 1
Phrase speech: 0
G2:
Nonverbal (